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Enhancing Administrative Claims Data: Feasibility, Validation and Application of Linking Medicare Claims Data and National Marrow Donor Program Search Data.
Preussler, Jaime M; Meyer, Christa L; Sees Coles, Jennifer A; Yoo, Dana; Mau, Lih-Wen; Garrett, Nicole D; Auletta, Jeffery J.
Afiliación
  • Preussler JM; National Marrow Donor Program/Be The Match, Minneapolis, MN.
  • Meyer CL; Center for International Blood and Marrow Transplant Research, Minneapolis, MN.
  • Sees Coles JA; National Marrow Donor Program/Be The Match, Minneapolis, MN.
  • Yoo D; Center for International Blood and Marrow Transplant Research, Minneapolis, MN.
  • Mau LW; National Marrow Donor Program/Be The Match, Minneapolis, MN.
  • Garrett ND; Center for International Blood and Marrow Transplant Research, Minneapolis, MN.
  • Auletta JJ; National Marrow Donor Program/Be The Match, Minneapolis, MN.
JCO Clin Cancer Inform ; 6: e2200069, 2022 10.
Article en En | MEDLINE | ID: mdl-36228178
PURPOSE: Administrative claims data provide real-world service utilization of acute myeloid leukemia (AML) treatment, but lacks insight into treatment delays or barriers. The National Marrow Donor Program (NMDP)/Be The Match Search (Search) data contains information on donor search, but lacks information on treatment received if allogeneic hematopoietic cell transplant (HCT) is not performed. We hypothesized that linking these two data sets would create a rich resource to define factors associated with receiving HCT that could not be evaluated with either data set alone. METHODS: A subset of 2010-2016 Medicare administrative claims data was linked with Search data. A total of 5,351 patients with AML age 65-74 years (HCT = 607, no HCT = 4,744) were identified using Medicare. These patients were then linked to 93,800 records with a donor search between 2009 and 2016. Patient date of birth, sex, disease, ZIP code, transplant center/hospital, and diagnosis date were used for matching. Exploratory analysis was conducted to identify predictors associated with receiving HCT for patients with AML who received a search. RESULTS: The data sets were successfully linked, showing high sensitivity and specificity. The final cohort included 5,085 patients with AML (HCT = 533, no HCT = 4,552). Of 97 patients who received HCT without a matched search, more than 85% received a related donor HCT. Of those not receiving HCT, 609 had a matched NMDP search and 3,943 did not have a matched NMDP search. Multivariate analysis showed time to search, age, diagnosis year, race/ethnicity, and neighborhood education status associated with receiving HCT. CONCLUSION: Methods herein demonstrate the feasibility of linking Search and Medicare data. Similar methods may be applied to answer critical questions regarding barriers to HCT, thereby identifying areas to improve access to care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Implementation_research Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: JCO Clin Cancer Inform Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Implementation_research Límite: Aged / Humans País/Región como asunto: America do norte Idioma: En Revista: JCO Clin Cancer Inform Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos