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Ultrasensitive colorimetric detection of fluoride and arsenate in water and mammalian cells using recyclable metal oxacalixarene probe: a lateral flow assay.
Dey, Shuvankar; Kumar, Anshu; Mondal, Pradip Kumar; Chopra, Deepak; Roy, Rupam; Jindani, Sana; Ganguly, Bishwajit; Mayya, Chaithra; Bhatia, Dhiraj; Jain, Vinod K.
Afiliación
  • Dey S; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India.
  • Kumar A; Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, 208016, India.
  • Mondal PK; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India.
  • Chopra D; Department of Chemistry, University of Delhi, New Delhi, 110007, India.
  • Roy R; Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, 562112, India.
  • Jindani S; Elettra-Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149, Basovizza Trieste, Italy.
  • Ganguly B; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal, 462066, India.
  • Mayya C; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal, 462066, India.
  • Bhatia D; Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal, 462066, India.
  • Jain VK; Computation and Simulation Unit (Analytical and Environmental Science Discipline and Centralized Instrument Facility), CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujarat, 364002, India.
Sci Rep ; 12(1): 17119, 2022 10 12.
Article en En | MEDLINE | ID: mdl-36224315
Globally 3 billion people are consuming water with moderately high concentrations of fluoride and arsenic. The development of a simple point of care (PoC) device or home device for the detection of fluoride/arsenic ensures safety before consuming water. Till date, lateral flow assay (LFA) based PoC devices can detect nucleic acids, viruses and diseases. An aluminium complex of rhodamine B functionalized oxacalix[4]arene (L) was designed to execute the LFA-based PoC device. Initially, Al3+ and Fe3+ ions were involved in complexation with the rhodamine B functionalized oxacalix[4]arene (L), resulting C1 (L-Al3+) and C2 (L-Fe3+) complexes respectively. The receptor L, as well as the probes (C1, C2), were characterized thoroughly using mass spectroscopy, FTIR, NMR, and EA. C1 and C2 were further utilized as recyclable probes for the detection of aqueous fluoride (21 ppb) and arsenate (1.92 ppb) respectively. The computational calculation indicates that upon complexation, the spirolactam ring opening at the rhodamine B site leads to optoelectronic changes. The consistency of LFA-based portable sensing device has been tested with water samples, synthetic fluoride standards and dental care products like toothpaste and mouthwash with concentrations ≥ 3 ppm. Moreover, fixed cell imaging experiments were performed to ascertain the in-vitro sensing phenomena.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Ácidos Nucleicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Ácidos Nucleicos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido