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2-BFI Provides Neuroprotection Against Fluorosis by Stabilizing Endoplasmic Reticulum-Mitochondria Contact Sites and Inhibiting Activation of the NLRP3 Inflammasome.
Chen, Rui; Xu, Wan; Sun, Yifu; Zhi, Rongrong; Xie, Peng; Zhi, Zhongwen; Tang, Xiaohong; Zhang, Caiyi.
Afiliación
  • Chen R; Department of Neurology, The Second People's Hospital of Huai'an and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Xu W; Department of Psychiatry and Mental Health, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • Sun Y; Department of Neurology, The Second People's Hospital of Huai'an and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Zhi R; Department of Gastroenterology, Lianshui County People's Hospital Affiliated to Kangda College of Nanjing Medical University, Huai'an, Jiangsu, China.
  • Xie P; Department of Neurosurgery, The Second People's Hospital of Huai'an and The Affiliated, Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Zhi Z; Department of Neurology, The Second People's Hospital of Huai'an and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.
  • Tang X; Department of Neurology, Hongze Huai'an District People's Hospital, Huai'an, Jiangsu, China. tangxiaohong852@163.com.
  • Zhang C; Department of Psychiatry and Psychology, Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, Xuzhou, Jiangsu, China. amanzcy@live.cn.
Neurochem Res ; 48(2): 591-603, 2023 Feb.
Article en En | MEDLINE | ID: mdl-36222959
2-(2-benzofu-ranyl)-2-imidazoline (2-BFI) is a drug that has attracted much attention in recent years. It has a therapeutic effect on brain diseases in animal models such as Alzheimer's disease and cerebral infarction. However, whether 2-BFI affords neuroprotection against the toxicity of fluoride, which can cross the blood-brain barrier and cause neurological dysfunction is not known. We investigated the cell viability and apoptosis of SH-SY5Y cells and primary cultures of cortical neurons exposed to fluoride, and 2-BFI was used to protect both two kinds of cells against the effects of fluoride. We found that 2-BFI can provide neuroprotection on SH-SY5Y cells and primary cultures of cortical neurons upon fluorosis by maintaining the stability of endoplasmic reticulum-mitochondria contact sites and inhibiting activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. This study may provide a new method for protecting against the neurotoxicity induced by fluoride exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inflamasomas / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: Neurochem Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inflamasomas / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: Neurochem Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos