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Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production.
Sugiyama, Yuta; Mori, Yumiko; Nara, Misaki; Kotani, Yusuke; Nagai, Emiko; Kawada, Hiroki; Kitamura, Mayu; Hirano, Rika; Shimokawa, Hiromi; Nakagawa, Akira; Minami, Hiromichi; Gotoh, Aina; Sakanaka, Mikiyasu; Iida, Noriho; Koyanagi, Takashi; Katayama, Takane; Okamoto, Shigefumi; Kurihara, Shin.
Afiliación
  • Sugiyama Y; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Mori Y; Gunma University Center for Food Science and Wellness, Gunma University, Maebashi, Japan.
  • Nara M; Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • Kotani Y; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Nagai E; Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • Kawada H; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Kitamura M; Department of Biotechnology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Bunkyo-ku, Japan.
  • Hirano R; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Shimokawa H; Department of Clinical Laboratory Sciences, Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • Nakagawa A; Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan.
  • Minami H; Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Japan.
  • Gotoh A; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Sakanaka M; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Iida N; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
  • Koyanagi T; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Katayama T; Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
  • Okamoto S; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
  • Kurihara S; Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
Gut Microbes ; 14(1): 2128605, 2022.
Article en En | MEDLINE | ID: mdl-36217238
Colonic luminal aromatic amines have been historically considered to be derived from dietary source, especially fermented foods; however, recent studies indicate that the gut microbiota serves as an alternative source of these amines. Herein, we show that five prominent genera of Firmicutes (Blautia, Clostridium, Enterococcus, Ruminococcus, and Tyzzerella) have the ability to abundantly produce aromatic amines through the action of aromatic amino acid decarboxylase (AADC). In vitro cultivation of human fecal samples revealed that a significant positive correlation between aadc copy number of Ruminococcus gnavus and phenylethylamine (PEA) production. Furthermore, using genetically engineered Enterococcus faecalis-colonized BALB/cCrSlc mouse model, we showed that the gut bacterial aadc stimulates the production of colonic serotonin, which is reportedly involved in osteoporosis and irritable bowel syndrome. Finally, we showed that human AADC inhibitors carbidopa and benserazide inhibit PEA production in En. faecalis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbidopa / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Gut Microbes Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbidopa / Microbioma Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Gut Microbes Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos