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Atrazine-induced oxidative damage via modulating xenobiotic-sensing nuclear receptors and cytochrome P450 systems in cerebrum and antagonism of lycopene.
Dai, Xue-Yan; Lin, Jia; Zhu, Shi-Yong; Guo, Jian-Ying; Cui, Jia-Gen; Li, Jin-Long.
Afiliación
  • Dai XY; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, PR China.
  • Lin J; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, 430023, PR China.
  • Zhu SY; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
  • Guo JY; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
  • Cui JG; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
  • Li JL; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin, 150030, PR China; Heilongjiang Key Laborat
Food Chem Toxicol ; 170: 113462, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36216167
Atrazine (ATR) is a widely used herbicide with biologically toxic effects that can lead to neurotoxicity. Lycopene (LYC) is an antioxidant with chemoprotective properties. However, little know about the mechanisms of preventative interventions about LYC alleviated ATR-induced neurotoxicity. Male mice were treated with distilled water (C), 5 mg/kg BW/day LYC (L), 50 and 200 mg/kg BW/day ATR (A1, A2), respectively and LYC + ATR (A1+L, A2+L). ATR promoted oxidative stress and inflammatory damage, as showed by the effects on MDA, H2O2, IL-6 and TNF-α accumulation, and IL-10, SOD, CAT and GSH depletion, which caused neuronal swelling and mitochondrial vacuolar degeneration. ATR disrupted the CYP450s balance via increasing contents of CYP450 and cytochrome B5, enhancing activities of NCR and ERND and activating NXRs and NXRs-related transcription factors. However, all these effects were reversed by LYC pretreatment. Collectively, these data indicated that LYC inhibited ATR-induced oxidative damage through modulating xenobiotic-sensing nuclear receptors and CYP450s.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrazina / Cerebro Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrazina / Cerebro Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido