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Differences in Olivo-Cerebellar Circuit and Cerebellar Network Connectivity in Essential Tremor: a Resting State fMRI Study.
Sharifi, Sarvi; Buijink, Arthur W G; Luft, Frauke; Scheijbeler, Elliz P; Potters, Wouter V; van Wingen, Guido; Heida, Tjitske; Bour, Lo J; van Rootselaar, Anne-Fleur.
Afiliación
  • Sharifi S; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, D2-113, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands. s.sharifi@amsterdamumc.nl.
  • Buijink AWG; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, D2-113, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
  • Luft F; Department of Biomedical Signals and Systems, University of Twente, TechMed Centre, Enschede, The Netherlands.
  • Scheijbeler EP; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan 1117, Amsterdam, The Netherlands.
  • Potters WV; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, D2-113, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
  • van Wingen G; Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
  • Heida T; Department of Biomedical Signals and Systems, University of Twente, TechMed Centre, Enschede, The Netherlands.
  • Bour LJ; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, D2-113, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
  • van Rootselaar AF; Department of Neurology and Clinical Neurophysiology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, D2-113, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Cerebellum ; 22(6): 1123-1136, 2023 Dec.
Article en En | MEDLINE | ID: mdl-36214998
The olivo-cerebellar circuit is thought to play a crucial role in the pathophysiology of essential tremor (ET). Whether olivo-cerebellar circuit dysfunction is also present at rest, in the absence of clinical tremor and linked voluntary movement, remains unclear. Assessing this network in detail with fMRI is challenging, considering the brainstem is close to major arteries and pulsatile cerebrospinal fluid-filled spaces obscuring signals of interest. Here, we used methods tailored to the analysis of infratentorial structures. We hypothesize that the olivo-cerebellar circuit shows altered intra-network connectivity at rest and decreased functional coupling with other parts of the motor network in ET. In 17 ET patients and 19 healthy controls, we investigated using resting state fMRI intracerebellar functional and effective connectivity on a dedicated cerebellar atlas. With independent component analysis, we investigated data-driven cerebellar motor network activations during rest. Finally, whole-brain connectivity of cerebellar motor structures was investigated using identified components. In ET, olivo-cerebellar pathways show decreased functional connectivity compared with healthy controls. Effective connectivity analysis showed an increased inhibitory influence of the dentate nucleus towards the inferior olive. Cerebellar independent component analyses showed motor resting state networks are less strongly connected to the cerebral cortex compared to controls. Our results indicate the olivo-cerebellar circuit to be affected at rest. Also, the cerebellum is "disconnected" from the rest of the motor network. Aberrant activity, generated within the olivo-cerebellar circuit could, during action, spread towards other parts of the motor circuit and potentially underlie the characteristic tremor of this patient group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temblor Esencial Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cerebellum Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Temblor Esencial Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cerebellum Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos