Targeting the innate repair receptor axis <i>via</i> erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice.

Dennhardt, Sophie; Pirschel, Wiebke; Wissuwa, Bianka; Imhof, Diana; Daniel, Christoph; Kielstein, Jan T; Hennig-Pauka, Isabel; Amann, Kerstin; Gunzer, Florian; Coldewey, Sina M

Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice.

Dennhardt, Sophie; Pirschel, Wiebke; Wissuwa, Bianka; Imhof, Diana; Daniel, Christoph; Kielstein, Jan T; Hennig-Pauka, Isabel; Amann, Kerstin; Gunzer, Florian; Coldewey, Sina M.

Afiliación

Dennhardt S; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Pirschel W; Septomics Research Center, Jena University Hospital, Jena, Germany.
Wissuwa B; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
Imhof D; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Daniel C; Septomics Research Center, Jena University Hospital, Jena, Germany.
Kielstein JT; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Hennig-Pauka I; Septomics Research Center, Jena University Hospital, Jena, Germany.
Amann K; Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, Bonn, Germany.
Gunzer F; Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany.
Coldewey SM; Medical Clinic V, Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany.

Front Immunol ; 13: 1010882, 2022.

Article en En | MEDLINE | ID: mdl-36211426

Asunto(s)

Eritropoyetina; Síndrome Hemolítico-Urémico; Escherichia coli Shiga-Toxigénica; Animales; Subunidad beta Común de los Receptores de Citocinas; Eritropoyetina/farmacología; Síndrome Hemolítico-Urémico/tratamiento farmacológico; Humanos; Ratones; Oligopéptidos; Receptores de Eritropoyetina; Toxinas Shiga; Porcinos

Palabras clave

erythropoietin; hemolytic-uremic syndrome; mice; microangiopathic hemolytic anemia; pyroglutamate helix B surface peptide; shiga toxin; thrombotic microangiopathy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Eritropoyetina / Escherichia coli Shiga-Toxigénica / Síndrome Hemolítico-Urémico Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

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