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Incidence, characteristics, and management of central nervous system metastases in patients with inflammatory breast cancer.
Warren, Laura E G; Niman, Samuel M; Remolano, Marie C; Landry, Jean M; Nakhlis, Faina; Bellon, Jennifer R; Aizer, Ayal A; Lin, Nancy U; Tolaney, Sara M; Regan, Meredith M; Overmoyer, Beth A; Lynce, Filipa.
Afiliación
  • Warren LEG; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.
  • Niman SM; Inflammatory Breast Cancer Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Remolano MC; Department of Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Landry JM; Inflammatory Breast Cancer Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Nakhlis F; Inflammatory Breast Cancer Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Bellon JR; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Aizer AA; Inflammatory Breast Cancer Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Lin NU; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.
  • Tolaney SM; Inflammatory Breast Cancer Program, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Regan MM; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.
  • Overmoyer BA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Lynce F; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Cancer ; 128(23): 4085-4094, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36210737
BACKGROUND: Patients with inflammatory breast cancer (IBC) have a high risk of central nervous system metastasis (mCNS). The purpose of this study was to quantify the incidence of and identify risk factors for mCNS in patients with IBC. METHODS: The authors retrospectively reviewed patients diagnosed with IBC between 1997 and 2019. mCNS-free survival time was defined as the date from the diagnosis of IBC to the date of diagnosis of mCNS or the date of death, whichever occurred first. A competing risks hazard model was used to evaluate risk factors for mCNS. RESULTS: A total of 531 patients were identified; 372 patients with stage III and 159 patients with de novo stage IV disease. During the study, there were a total of 124 patients who had mCNS. The 1-, 2-, and 5-year incidence of mCNS was 5%, 9%, and 18% in stage III patients (median follow-up: 5.6 years) and 17%, 30%, and 42% in stage IV patients (1.8 years). Multivariate analysis identified triple-negative tumor subtype as a significant risk factor for mCNS for stage III patients. For patients diagnosed with metastatic disease, visceral metastasis as first metastatic site, triple-negative subtype, and younger age at diagnosis of metastases were risk factors for mCNS. CONCLUSIONS: Patients with IBC, particularly those with triple-negative IBC, visceral metastasis, and those at a younger age at diagnosis of metastatic disease, are at significant risk of developing mCNS. Further investigation into prevention of mCNS and whether early detection of mCNS is associated with improved IBC patient outcomes is warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias del Sistema Nervioso Central / Neoplasias Inflamatorias de la Mama Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Cancer Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias del Sistema Nervioso Central / Neoplasias Inflamatorias de la Mama Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans Idioma: En Revista: Cancer Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos