Crystal structure of a Burkholderia peptidase and modification of the substrate-binding site for enhanced hydrolytic activity toward gluten-derived pro-immunogenic peptides.

Liu, Yu-You; Lin, I-Chen; Chen, Pei-Cih; Lee, Cheng-Cheng; Meng, Menghsiao

Liu, Yu-You; Lin, I-Chen; Chen, Pei-Cih; Lee, Cheng-Cheng; Meng, Menghsiao.

Afiliación

Liu YY; Ph.D. Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, 250 Kuo-Kuang Rd., Taichung 40227; 128 Academia Road, Section 2, Nankang, Taipei 11529, Taiwan.
Lin IC; Graduate Institute of Biotechnology, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan.
Chen PC; Graduate Institute of Biotechnology, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan.
Lee CC; Graduate Institute of Biotechnology, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan.
Meng M; Graduate Institute of Biotechnology, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 40227, Taiwan. Electronic address: mhmeng@dragon.nchu.edu.tw.

Int J Biol Macromol ; 222(Pt B): 2258-2269, 2022 Dec 01.

Article en En | MEDLINE | ID: mdl-36209912

Asunto(s)

Burkholderia; Enfermedad Celíaca; Humanos; Glútenes/metabolismo; Péptido Hidrolasas; Burkholderia/metabolismo; Péptidos/química; Sitios de Unión

Palabras clave

Burkholderia gladioli; Celiac disease; Glutenase; Serine peptidase; Toxic gluten peptides

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca / Burkholderia Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos

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