Early transformation event from follicular lymphoma: our experience of four cases.
Pol J Pathol
; 73(2): 166-175, 2022.
Article
en En
| MEDLINE
| ID: mdl-36200794
Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by the acquisition of additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four such cases of FL that transformed into more aggressive B-cell non-Hodgkin lymphomas within six months of their initial diagnosis. Subsequent testing of c-myc, P53 and cyclin D1 by immunohistochemistry and fluorescence in situ hybridization was done to further analyse their role in the process of transformation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfoma Folicular
/
Linfoma de Células B Grandes Difuso
Límite:
Humans
Idioma:
En
Revista:
Pol J Pathol
Asunto de la revista:
PATOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Polonia