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Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial.
Djurhuus, Sissal Sigmundsdóttir; Schauer, Tim; Simonsen, Casper; Toft, Birgitte Grønkaer; Jensen, Adina Ruth Deborah; Erler, Janine Terra; Røder, Martin Andreas; Hojman, Pernille; Brasso, Klaus; Christensen, Jesper Frank.
Afiliación
  • Djurhuus SS; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Schauer T; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Simonsen C; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Toft BG; Department of Pathology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Jensen ARD; Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen, Denmark.
  • Erler JT; Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen, Denmark.
  • Røder MA; Department of Urology, Copenhagen Prostate Cancer Center, Copenhagen University Hospital -Rigshospitalet, Copenhagen, Denmark.
  • Hojman P; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Brasso K; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
  • Christensen JF; Department of Urology, Copenhagen Prostate Cancer Center, Copenhagen University Hospital -Rigshospitalet, Copenhagen, Denmark.
Physiol Rep ; 10(19): e15408, 2022 10.
Article en En | MEDLINE | ID: mdl-36199257
Postdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential anticancer effects, but these remain poorly explored in clinical settings. The objective of this study was to explore the effects of a single exercise bout on tumor oxygenation and immune cell infiltration in patients with prostate cancer. Thirty patients with localized prostate cancer were randomized (2:1) to either one high-intensity interval training bout or no exercise on the day before radical prostatectomy. Immunohistochemical analyses were performed on prostatic tissue from surgery and assessed for tumor hypoxia, natural killer (NK) cell infiltration, and microvessel density (MVD). Acute systemic response in blood lymphocytes, epinephrine, norepinephrine, IL-6, tumor necrosis factor, cortisol, lactate, and glucose was also evaluated. We did not find between-group differences in tumor hypoxia (Mann-Whitney U test, U = 83.5, p = 0.604) or NK cell infiltration (U = 77.0, p = 0.328). Also, no significant correlation was found between MVD and tumor hypoxia or NK cell infiltration. One exercise bout is likely insufficient to modulate tumor hypoxia or NK cell infiltration. Future studies may elucidate if an accumulation of several exercise bouts can impact these outcomes (NCT03675529, www.clinicaltrials.gov).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Hidrocortisona Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Revista: Physiol Rep Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Hidrocortisona Tipo de estudio: Clinical_trials Límite: Humans / Male Idioma: En Revista: Physiol Rep Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos