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Breast cancer risk in Ukrainian women exposed to Chornobyl fallout while pregnant or lactating: standardized incidence ratio analysis, 1998 to 2016.
Vij, Vibha; Shpak, Victor; Zamotayeva, Galyna; Lapikura, Oles; Ryzhov, Anton; Gorokh, Evgeniy; Zhang, Rui; Mabuchi, Kiyohiko; Little, Mark P; Drozdovitch, Vladimir; Chizhov, Konstantin; Masuik, Sergii; Preston, Dale; Tronko, Mykola; Cahoon, Elizabeth K.
Afiliación
  • Vij V; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA. vibha.vij@nih.gov.
  • Shpak V; V.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
  • Zamotayeva G; V.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
  • Lapikura O; V.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
  • Ryzhov A; Taras Shevchenko National University of Kyiv, Kyiv, 01033, Ukraine.
  • Gorokh E; National Cancer Registry of Ukraine, National Cancer Institute, Kyiv, 03022, Ukraine.
  • Zhang R; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
  • Mabuchi K; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
  • Little MP; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
  • Drozdovitch V; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
  • Chizhov K; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
  • Masuik S; National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, 04050, Ukraine.
  • Preston D; Hirosoft International, Eureka, CA, USA.
  • Tronko M; V.P. Komisarenka Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, 04114, Ukraine.
  • Cahoon EK; Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD, 20892-9778, USA.
Eur J Epidemiol ; 37(11): 1195-1200, 2022 Nov.
Article en En | MEDLINE | ID: mdl-36197563
The radiation-related risk of breast cancer among women following the Chornobyl accident remains uncertain. During pregnancy, there is rapid cell proliferation in the breast while radioactive iodine from fallout exposure can concentrate in lactating breast tissues. We conducted a standardized incidence ratio (SIR) analysis of breast cancer in a cohort of 2,631 women who were lactating and/or pregnant at any time during the 2-month period of radioiodine fallout (April 26, 1986-June 30, 1986). There were 37,151 person-years of follow-up, and 26 incident breast cancers were identified through linkage with the National Cancer Registry of Ukraine. Breast cancer rates among pregnant or lactating women were compared to the general population rates, and SIRs were adjusted for oblast, urban/rural, age, and calendar year. The SIR was not significant for women pregnant at the time of the accident (SIR = 0.75; 95% CI 0.44, 1.18) or for women lactating anytime within 2 months of the accident (SIR = 0.96; 95% CI 0.48, 1.68). However, there was a non-significantly elevated risk for women lactating at the time of accident (SIR = 1.30, 95% CI 0.40, 3.01). The increased SIR for breast cancer among lactating women is consistent with the results of a similar study in Belarus and indicates the need to quantify the radiation risk of breast cancer in a larger study of women lactating during the period of fallout exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias de la Tiroides / Accidente Nuclear de Chernóbil / Neoplasias Inducidas por Radiación Tipo de estudio: Etiology_studies / Incidence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Eur J Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias de la Tiroides / Accidente Nuclear de Chernóbil / Neoplasias Inducidas por Radiación Tipo de estudio: Etiology_studies / Incidence_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Eur J Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos