Your browser doesn't support javascript.
loading
Cord blood immune profile: Associations with higher prenatal plastic chemical levels.
Eisner, Alex; Gao, Yuan; Collier, Fiona; Drummond, Katherine; Thomson, Sarah; Burgner, David; Vuillermin, Peter; Tang, Mimi Lk; Mueller, Jochen; Symeonides, Christos; Saffery, Richard; Ponsonby, Anne-Louise.
Afiliación
  • Eisner A; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
  • Gao Y; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia; Child Health Research Unit, Barwon Health, Geelong, Victoria, Australia.
  • Collier F; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia; Child Health Research Unit, Barwon Health, Geelong, Victoria, Australia.
  • Drummond K; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
  • Thomson S; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
  • Burgner D; Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia.
  • Vuillermin P; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Victoria, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
  • Tang ML; Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia; Melbourne University, Melbourne, Victoria, Australia; Royal Children's Hospital, Melbourne, Victoria, Australia.
  • Mueller J; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Brisbane, Queensland, Australia.
  • Symeonides C; Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia; The Minderoo Foundation, Perth, Western Australia, Australia; Royal Children's Hospital, Melbourne, Victoria, Australia.
  • Saffery R; Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
  • Ponsonby AL; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia. Electronic address: annelouise.ponsonby@florey.edu.au.
Environ Pollut ; 315: 120332, 2022 Dec 15.
Article en En | MEDLINE | ID: mdl-36195195
Prenatal exposure to plastic chemicals has been associated with alterations to early-life immune function in children. However, previous studies have generally been small and focused on limited repertoires of immune indices. In a large population-based pre-birth cohort (n = 1074), third-trimester measurements of eight phthalate metabolites and three analogues of bisphenols were used to estimate prenatal exposure to phthalate and bisphenol compounds. In cord blood, immune cell populations were measured by flow cytometry and an extensive panel of cytokines and chemokines were measured by multiplex immunoassay. We used these cord blood analytes to estimate "early life" immune profiles. The full study sample comprises data from 774 infants with prenatal plastic metabolite measurements and any cord blood immune data. Multiple linear regression analysis was used to evaluate whether prenatal phthalate and bisphenol exposure was prospectively associated with cord blood immune cell populations and cytokine and chemokine levels. Generally, inverse associations were observed between prenatal phthalate exposure and cord blood immune indices. Higher exposure to di-n-butyl phthalate was associated with lower cord blood levels of platelet-derived growth factor (PDGF) and interferon gamma-induced protein 10 (IP-10); higher exposure to the sum of dibutyl phthalates was associated with lower cord blood levels of IP-10; and higher exposure to benzyl butyl phthalate was associated with lower cord blood levels of interleukin 1 beta (IL-1ß). There was less evidence of associations between bisphenols and cord blood immune indices. These results extend previous work examining prenatal plastic chemical exposure and early-life immune development and highlight the importance of further examination of potential associations with health-related outcomes.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Efectos Tardíos de la Exposición Prenatal / Contaminantes Ambientales Tipo de estudio: Risk_factors_studies Límite: Child / Female / Humans / Infant / Pregnancy Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Efectos Tardíos de la Exposición Prenatal / Contaminantes Ambientales Tipo de estudio: Risk_factors_studies Límite: Child / Female / Humans / Infant / Pregnancy Idioma: En Revista: Environ Pollut Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido