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Predictive value of early kinetics of ctDNA combined with cfDNA and serum CEA for EGFR-TKI treatment in advanced non-small cell lung cancer.
Zheng, Jie; Wang, Yubo; Hu, Chen; Zhu, Mengxiao; Ii, Jianghua; Lin, Caiyu; Lu, Conghua; Dou, Yuanyao; Zhao, Chenlong; Zhang, Yimin; Wu, Di; Li, Li; Tang, Huan; He, Tingting; Pan, Chunxiao; Han, Rui; He, Yong.
Afiliación
  • Zheng J; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Wang Y; School of Medicine, Chongqing University, Chongqing, China.
  • Hu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Zhu M; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Ii J; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Dou Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Zhao C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Zhang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Wu D; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Tang H; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • He T; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Pan C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
  • Han R; Burning Rock Biotech, Guangzhou, China.
  • He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Thorac Cancer ; 13(22): 3162-3173, 2022 11.
Article en En | MEDLINE | ID: mdl-36193794
BACKGROUND: Circulating tumor DNA (ctDNA) has made a breakthrough as an early biomarker in operable early-stage cancer patients. However, the function of ctDNA combined with cell-free DNA (cfDNA) as a predictor in advanced non-small cell lung cancer (NSCLC) remains unknown. Here, we explored its potential as a biomarker for predicting the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with advanced NSCLC. METHODS: A retrospective analysis was undertaken. Plasma collected from 51 patients with advanced NSCLC prior to and serially after starting treatment with EGFR-TKIs was analyzed by next-generation sequencing (NGS). The performance of ctDNA, cfDNA, and combining ctDNA with cfDNA were evaluated for their ability to predict survival outcomes. RESULTS: Patients with early undetectable ctDNA and increasing cfDNA had a markedly better progression-free survival (PFS) (p < 0.001) and overall survival (OS) (p = 0.001) than those with early detectable ctDNA and decreasing cfDNA. Patients with early ctDNA clearance were more likely to have the ctDNA persistent clearance (p = 0.006). The early clearance rate of ctDNA in the normal carcinoembryonic antigen (CEA) group was significantly higher than in the low and high groups (p = 0.028). Patients with greater CEA decline had a higher early clearance rate of ctDNA than those with minor CEA change (p = 0.016). CONCLUSIONS: We based this study on ctDNA and cfDNA, explored its prognostic predictive ability, and combined CEA to monitor EGFR-TKI efficacy. This study may provide new perspectives and insights into the precise treatment strategies for NSCLC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Ácidos Nucleicos Libres de Células / ADN Tumoral Circulante / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Thorac Cancer Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Ácidos Nucleicos Libres de Células / ADN Tumoral Circulante / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Thorac Cancer Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur