2D, Two Dimensional; 3D, Three Dimensional; ADME, Absorption, Distribution, Metabolism, and Excretion; AFA DESI-MSI, Air flow-assisted desorption electrospray ionization mass spectrometry imaging; AI, Artificial Intelligence; Active ingredient; CDE, Center for Drug Evaluation; COX-2, Cyclooxygenase 2; Chemical components; Chinese medicine formula; Compound; Disease Targets; GC-MS, Gas chromatography-mass spectrometry; HPLC, High Performance Liquid Chromatography; HR-MS, High Resolution Mass Spectrometry; HTS, High Throughput Screening; HUA, hyperuricemia; ICPMS, inductively coupled plasma mass spectrometry; MALDI MS, Matrix for surface-assisted laser desorption/ionization mass spectrometry; MD, Microdialysis; MI, Molecular imprinting; MSI, Mass spectrometry imaging; Mass Spectrometry; NL/PR, Neutral loss/precursor ion; NMPA, National Medical Products Administration; OPLS-DA, Orthogonal partial least squares discriminant analysis; PD, Pharmacodynamic; PK, Pharmacokinetic; Q-TOF/MS, Quadrupole time-of-flight mass spectrometry; QSAR, Quantitative structure-activity relationship; QqQ-MS, Triple quadruple mass spectrometry; R-strategy, Reduce strategy; TCM, Traditional Chinese medicine; UF, Affinity ultrafiltration; UPLC, Ultra Performance Liquid Chromatography; XO, Xanthine oxidase