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Apolipoprotein E knockout may affect cognitive function in D-galactose-induced aging mice through the gut microbiota-brain axis.
Chen, Bowei; Yi, Jian; Xu, Yaqian; Wen, Huiqiao; Tian, Fengming; Liu, Yingfei; Xiao, Lan; Li, Lisong; Liu, Baiyan.
Afiliación
  • Chen B; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Yi J; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Xu Y; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Wen H; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Tian F; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Liu Y; The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, China.
  • Xiao L; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • Li L; College of Information Science and Engineering, Hunan University of Chinese Medicine, Changsha, China.
  • Liu B; Hunan Academy of Chinese Medicine, Changsha, China.
Front Neurosci ; 16: 939915, 2022.
Article en En | MEDLINE | ID: mdl-36188475
The gut microbiota plays an important role in central nervous system (CNS) disorders. Apolipoprotein E (ApoE) can affect the composition of the gut microbiota and is closely related to the CNS. However, the mechanism by which ApoE affects cognitive dysfunction through the gut microbiota-brain axis has thus far not been investigated. In this study, we used wild-type mice and ApoE knockout (ApoE-/-) mice to replicate the aging model and examined the effects of ApoE deletion on cognitive function, hippocampal ultrastructure, synaptophysin (SYP) and postsynaptic density 95 (PSD-95) in aging mice. We also explored whether ApoE deletion affects the gut microbiota and the metabolite profile of the hippocampus in aging mice and finally examined the effect of ApoE deletion on lipids and oxidative stress in aging mice. The results showed that the deletion of ApoE aggravated cognitive dysfunction, hippocampal synaptic ultrastructural damage and dysregulation of SYP and PSD-95 expression in aging mice. Furthermore, ApoE deletion reduced gut microbial makeup in aging mice. Further studies showed that ApoE deletion altered the hippocampal metabolic profile and aggravated dyslipidemia and oxidative stress in aging mice. In brief, our findings suggest that loss of ApoE alters the composition of the gut microbiota, which in turn may affect cognitive function in aging mice through the gut microbiota-brain axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza