Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-&#954;B and MAPK signaling.

Chen, Xin-Sen; Wang, Shu-Hang; Liu, Chen-Yan; Gao, Yu-Lei; Meng, Xiang-Long; Wei, Wei; Shou, Song-Tao; Liu, Yan-Cun; Chai, Yan-Fen

Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.

Chen, Xin-Sen; Wang, Shu-Hang; Liu, Chen-Yan; Gao, Yu-Lei; Meng, Xiang-Long; Wei, Wei; Shou, Song-Tao; Liu, Yan-Cun; Chai, Yan-Fen.

Afiliación

Chen XS; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Wang SH; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Liu CY; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Gao YL; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Meng XL; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Wei W; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Shou ST; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.
Liu YC; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China. Electronic address: yancunliu@tmu.edu.cn.
Chai YF; Department of Emergency Medicine, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China. Electronic address: chaiyanfen2012@126.com.

Pharmacol Res ; 185: 106473, 2022 11.

Article en En | MEDLINE | ID: mdl-36182039

Asunto(s)

Cardiomiopatías; Sepsis; Ratones; Animales; Losartán/farmacología; Losartán/uso terapéutico; FN-kappa B/metabolismo; Antagonistas de Receptores de Angiotensina; Receptor Toll-Like 4; Bloqueadores del Receptor Tipo 1 de Angiotensina II/farmacología; Bloqueadores del Receptor Tipo 1 de Angiotensina II/uso terapéutico; Proteínas Quinasas Activadas por Mitógenos; Inhibidores de la Enzima Convertidora de Angiotensina; Receptor de Angiotensina Tipo 1/metabolismo; Angiotensina II/farmacología; Sepsis/complicaciones; Sepsis/tratamiento farmacológico; Cardiomiopatías/tratamiento farmacológico; Cardiomiopatías/etiología; Macrófagos/metabolismo

Palabras clave

Angiotensin II type 1 receptor; Apoptosis; Losartan; Macrophage polarization; Sepsis-induced cardiomyopathy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sepsis / Cardiomiopatías Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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