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Shedding of infectious SARS-CoV-2 despite vaccination.
Riemersma, Kasen K; Haddock, Luis A; Wilson, Nancy A; Minor, Nicholas; Eickhoff, Jens; Grogan, Brittany E; Kita-Yarbro, Amanda; Halfmann, Peter J; Segaloff, Hannah E; Kocharian, Anna; Florek, Kelsey R; Westergaard, Ryan; Bateman, Allen; Jeppson, Gunnar E; Kawaoka, Yoshihiro; O'Connor, David H; Friedrich, Thomas C; Grande, Katarina M.
Afiliación
  • Riemersma KK; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, United States of America.
  • Haddock LA; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, United States of America.
  • Wilson NA; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Minor N; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Eickhoff J; Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Grogan BE; Public Health Madison & Dane County, Madison, Wisconsin, United States of America.
  • Kita-Yarbro A; Public Health Madison & Dane County, Madison, Wisconsin, United States of America.
  • Halfmann PJ; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, United States of America.
  • Segaloff HE; Epidemic Intelligence Service, CDC, Atlanta, Georgia, United States of America.
  • Kocharian A; Wisconsin Department of Health Services, Madison, Wisconsin, United States of America.
  • Florek KR; Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, United States of America.
  • Westergaard R; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Bateman A; Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, United States of America.
  • Jeppson GE; Exact Sciences, Madison, Wisconsin, United States of America.
  • Kawaoka Y; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, United States of America.
  • O'Connor DH; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin, United States of America.
  • Grande KM; Public Health Madison & Dane County, Madison, Wisconsin, United States of America.
PLoS Pathog ; 18(9): e1010876, 2022 09.
Article en En | MEDLINE | ID: mdl-36178969
The SARS-CoV-2 Delta Variant of Concern is highly transmissible and contains mutations that confer partial immune escape. The emergence of Delta in North America caused the first surge in COVID-19 cases after SARS-CoV-2 vaccines became widely available. To determine whether individuals infected despite vaccination might be capable of transmitting SARS-CoV-2, we compared RT-PCR cycle threshold (Ct) data from 20,431 test-positive anterior nasal swab specimens from fully vaccinated (n = 9,347) or unvaccinated (n = 11,084) individuals tested at a single commercial laboratory during the interval 28 June- 1 December 2021 when Delta variants were predominant. We observed no significant effect of vaccine status alone on Ct value, nor when controlling for vaccine product or sex. Testing a subset of low-Ct (<25) samples, we detected infectious virus at similar rates, and at similar titers, in specimens from vaccinated and unvaccinated individuals. These data indicate that vaccinated individuals infected with Delta variants are capable of shedding infectious SARS-CoV-2 and could play a role in spreading COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Virales / COVID-19 Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos