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Short-term DAPT after coronary stenting has similar ischemic and bleeding outcomes as long-term DAPT: a 5-year population-based cohort study.
Balaji Srinivasan, Sriraag; Sehly, Amro; Jaltotage, Biyanka; Qin, Simon; Ihdayhid, Abdul Rahman; Marangou, James; Rankin, James M; Sanfilippo, Frank M; Dwivedi, Girish.
Afiliación
  • Balaji Srinivasan S; Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
  • Sehly A; School of Medicine, University of Western Australia, Perth, WA, Australia.
  • Jaltotage B; Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
  • Qin S; Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
  • Ihdayhid AR; School of Population and Global Health, University of Western Australia, Perth, WA, Australia.
  • Marangou J; Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
  • Rankin JM; Harry Perkins Institute of Medical Research, Perth, WA, Australia.
  • Sanfilippo FM; Medical School, Curtin University, Perth, WA, Australia.
  • Dwivedi G; Department of Cardiology, Fiona Stanley Hospital, Perth, WA, Australia.
Ir J Med Sci ; 192(4): 1645-1647, 2023 Aug.
Article en En | MEDLINE | ID: mdl-36173545
BACKGROUND: Optimal duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) remains controversial. AIM: We investigated the relationship between DAPT duration following PCI and long-term ischemic and bleeding outcomes under real-world conditions. METHODS: Patients aged ≥ 65 years who underwent PCI with stenting in Western Australian hospitals between 2003 and 2008 and survived 2 years were identified from linked hospital admissions data. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE) defined as a composite of all-cause death and admissions for acute coronary syndrome (ACS), coronary artery revascularization procedure, stroke, and major bleeding. Secondary outcomes were ACS admissions, all-cause death, and major bleeding admissions. Patients were followed up for 5 years from initial PCI. RESULTS: A total of 3963 patients were included in the final analysis. The mean age of the cohort was 74.5 ± 6.1 years with 67.3% males. No significant difference was seen with 6-12, 12-18, or 18-24 months DAPT, compared to 0-6 months DAPT duration for MACCE and all secondary outcomes at 3- and 5-year post-PCI. CONCLUSION: There is no significant difference in both bleeding and ischemic outcomes in long-term DAPT as compared to short-term DAPT for first- and second-generation drug-eluting stents in a real-world population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Intervención Coronaria Percutánea Tipo de estudio: Etiology_studies / Observational_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Ir J Med Sci Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Coronario Agudo / Intervención Coronaria Percutánea Tipo de estudio: Etiology_studies / Observational_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Ir J Med Sci Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Irlanda