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Loss of p16 expression is a risk factor for recurrence in sinonasal inverted papilloma.
Menendez, M; Cabal, V N; Vivanco, B; Suarez-Fernandez, L; Lopez, F; Llorente, J L; Hermsen, M A; Alvarez-Marcos, C.
Afiliación
  • Menendez M; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Cabal VN; Department of Head and Neck Oncology, Instituto de Investigacion Sanitaria del Principado de Asturias, Oviedo, Spain.
  • Vivanco B; Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Suarez-Fernandez L; Department of Head and Neck Oncology, Instituto de Investigacion Sanitaria del Principado de Asturias, Oviedo, Spain.
  • Lopez F; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Llorente JL; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • Hermsen MA; Department of Head and Neck Oncology, Instituto de Investigacion Sanitaria del Principado de Asturias, Oviedo, Spain.
  • Alvarez-Marcos C; Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Rhinology ; 60(6): 453-461, 2022 Dec 01.
Article en En | MEDLINE | ID: mdl-36173184
BACKGROUND: The purpose of this study was to evaluate p16, p53, EGFR, pEGFR protein expression and HPV infection as possible markers of tumor progression in a series of sinonasal inverted papilloma (SNIP) and sinonasal squamous cell carcinoma (SNSCC). METHODS: A series of 49 SNIP, 11 SNSCC associated with SNIP (SNIP-SNSCC) and 52 SNSCC not associated with SNIP were analyzed for p16, p53, EGFR, and phosphorylated EGFR (pEGFR) expression by immunohistochemistry. Human papillomavirus (HPV) infection status was evaluated by DNA-PCR. Results were correlated to clinical and follow-up data. RESULTS: Reduced or loss of p16 expression was observed in 18% SNIP, 64% SNIP-SNSCC and 87% of SNSCC. Reduced or loss p16 staining in SNIP correlated with shorter recurrent SNIP-free follow-up. In contrast, p16 expression was not predictive of recurrent SNSCC in cases with SNIP-SNSCC and SNSCC. P53, EGFR, and pEGFR expression did not differ between the tumor groups, nor were they related to recurrent SNIP-free follow-up or recurrent SNSCC. Oncogenic HPV types 16 and 18 were detected in 5% of SNIP and 18% of SNIP-SNSCC, but not in SNSCC. There was no correlation between HPV infection and >70% p16 immunostaining. CONCLUSIONS: HPV infection appears to play a minor role in SNIP and SNSCC and p16 immunostaining does not appear a valid surrogate marker for HPV. However, reduced or loss p16 expression may have prognostic value as a risk marker for recurrent SNIP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Carcinoma de Células Escamosas / Papiloma Invertido / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rhinology Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Senos Paranasales / Carcinoma de Células Escamosas / Papiloma Invertido / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Rhinology Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos