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Intact finger representation within primary sensorimotor cortex of musician's dystonia.
Sadnicka, Anna; Wiestler, Tobias; Butler, Katherine; Altenmüller, Eckart; Edwards, Mark J; Ejaz, Naveed; Diedrichsen, Jörn.
Afiliación
  • Sadnicka A; Movement Disorders and Neuromodulation Group, St. George's University of London, London SW17 0RE, UK.
  • Wiestler T; Department of Clinical and Movement Neurosciences, University College London, London WC1N 3BG, UK.
  • Butler K; Department of Clinical and Movement Neurosciences, University College London, London WC1N 3BG, UK.
  • Altenmüller E; Faculty of Health, School of Health Professions, University of Plymouth, Plymouth PL4 4AA, UK.
  • Edwards MJ; Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.
  • Ejaz N; London Hand Therapy, King Edward VII's Hospital, London W1G 9QG, UK.
  • Diedrichsen J; Institute of Music Physiology and Musicians' Medicine, Hannover University of Music, Drama and Media, 30175 Hannover, Germany.
Brain ; 146(4): 1511-1522, 2023 04 19.
Article en En | MEDLINE | ID: mdl-36170332
Musician's dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organization of finger representations within primary somatosensory cortex. Here, we tested this hypothesis by investigating the finger-specific activity patterns in the primary somatosensory and motor cortex using functional MRI and multivariate pattern analysis in nine musicians with dystonia and nine healthy musicians. A purpose-built keyboard device allowed characterization of activity patterns elicited during passive extension and active finger presses of individual fingers. We analysed the data using both traditional spatial analysis and state-of-the art multivariate analyses. Our analysis reveals that digit representations in musicians were poorly captured by spatial analyses. An optimized spatial metric found clear somatotopy but no difference in the spatial geometry between fingers with dystonia. Representational similarity analysis was confirmed as a more reliable technique than all spatial metrics evaluated. Significantly, the dissimilarity architecture was equivalent for musicians with and without dystonia. No expansion or spatial shift of digit representation maps were found in the symptomatic group. Our results therefore indicate that the neural representation of generic finger maps in primary sensorimotor cortex is intact in musician's dystonia. These results speak against the idea that task-specific dystonia is associated with a distorted hand somatotopy and lend weight to an alternative hypothesis that task-specific dystonia is due to a higher-order disruption of skill encoding. Such a formulation can better explain the task-specific deficit and offers alternative inroads for therapeutic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Distónicos / Distonía / Corteza Sensoriomotora / Música Límite: Humans Idioma: En Revista: Brain Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Distónicos / Distonía / Corteza Sensoriomotora / Música Límite: Humans Idioma: En Revista: Brain Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido