The comparison of transforming growth factor beta-1 serum levels in early-stage breast cancer patients treated with external beam whole breast irradiation plus boost versus interstitial brachytherapy accelerated partial breast irradiation.
Brachytherapy
; 21(6): 748-753, 2022.
Article
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| MEDLINE
| ID: mdl-36167654
PURPOSE: Transforming growth factor beta-1 (TGF-ß1) is a profibrotic cytokine used as an early biomarker to develop radiation-induced fibrosis (RIF). This study aimed to compare TGF-ß1 serum levels in early-stage breast cancer patients treated with whole-breast radiation therapy (WBRT) plus boost versus accelerated partial breast irradiation (APBI) using multicatheter interstitial brachytherapy. METHODS AND MATERIALS: This clinical trial study was conducted on 20 women with early-stage breast cancer after breast-conserving surgery candidate for adjuvant radiotherapy in Golestan hospital, Ahvaz, in 2021. In one group APBI with high-dose-rate brachytherapy (nâ¯=â¯10), the other group WBRT with external beam radiation plus boost (nâ¯=â¯10) was performed. Serum level of TGF-ß1 was evaluated before radiotherapy, immediately after the end of radiotherapy and three months after the end of radiotherapy by Enzyme-linked immunosorbent assay technique (ELISA). RESULTS: Median serum TGF-ß1 level before radiotherapy was not significantly different between the two groups (pâ¯=â¯0.971). In both APBI and WBRT groups, serum TGF-ß1 levels significantly decreased immediately after radiotherapy compared to before treatment (pâ¯=â¯0.005 and pâ¯=â¯0.007, respectively); But three months after radiotherapy, serum TGF-ß1 levels increased significantly in the WBRT group (40.50 to 77.41 pg/mL; pâ¯=â¯0.017), while no significant change was observed in the APBI group (24.75 to 30.50 pg/mL; pâ¯=â¯0.332). CONCLUSIONS: Higher TGF-ß1 values in the WBRT group after radiotherapy can be used as an early and vital biomarker in this treatment, and this data may corroborate links between TGF-beta1 and fibrosis and fibrosis rates between APBI and WBRT; It also shows the preference for using the brachytherapy technique in this group of patients. However, due to the small number of samples, definitive conclusions require further prospective studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Braquiterapia
/
Neoplasias de la Mama
Tipo de estudio:
Observational_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Brachytherapy
Asunto de la revista:
RADIOTERAPIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Estados Unidos