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Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro.
Galal, Kareem A; Truong, Anna; Kwarcinski, Frank; de Silva, Chandi; Avalani, Krisha; Havener, Tammy M; Chirgwin, Michael E; Merten, Eric; Ong, Han Wee; Willis, Caleb; Abdelwaly, Ahmad; Helal, Mohamed A; Derbyshire, Emily R; Zutshi, Reena; Drewry, David H.
Afiliación
  • Galal KA; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Truong A; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
  • Kwarcinski F; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • de Silva C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Avalani K; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Chirgwin ME; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
  • Merten E; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Ong HW; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • Willis C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
  • Abdelwaly A; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12587, Egypt.
  • Helal MA; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12587, Egypt.
  • Derbyshire ER; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
  • Zutshi R; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
  • Drewry DH; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, North Carolina 27710, United States.
J Med Chem ; 65(19): 13172-13197, 2022 10 13.
Article en En | MEDLINE | ID: mdl-36166733
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parásitos / Plasmodium / Antimaláricos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parásitos / Plasmodium / Antimaláricos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos