Disruption of histamine/H<sub>1</sub>R-STAT3-SLC7A11 axis exacerbates doxorubicin-induced cardiac ferroptosis.

Zhu, Xiaowei; Wang, Xiangfei; Zhu, Baoling; Ding, Suling; Shi, Hongyu; Yang, Xiangdong

Disruption of histamine/H₁R-STAT3-SLC7A11 axis exacerbates doxorubicin-induced cardiac ferroptosis.

Zhu, Xiaowei; Wang, Xiangfei; Zhu, Baoling; Ding, Suling; Shi, Hongyu; Yang, Xiangdong.

Afiliación

Zhu X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhu B; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Ding S; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shi H; Department of Cardiology, Wusong Hospital of Zhongshan Hospital, Fudan University, Shanghai, 20094, China.
Yang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China; Department of Cardiology, Wusong Hospital of Zhongshan Hospital, Fudan University, Shanghai, 20094, China; Depar

Free Radic Biol Med ; 192: 98-114, 2022 11 01.

Article en En | MEDLINE | ID: mdl-36165929

Asunto(s)

Ferroptosis; Histamina; Animales; Cardiotoxicidad/genética; Doxorrubicina/metabolismo; Doxorrubicina/toxicidad; Ferroptosis/genética; Histamina/metabolismo; Histamina/farmacología; Antagonistas de los Receptores Histamínicos/metabolismo; Antagonistas de los Receptores Histamínicos/farmacología; Antagonistas de los Receptores Histamínicos H1/farmacología; Histidina Descarboxilasa/metabolismo; Histidina Descarboxilasa/farmacología; Ratones; Ratones Noqueados; Miocitos Cardíacos/metabolismo; Preparaciones Farmacéuticas/metabolismo

Palabras clave

DOX-Induced cardiotoxicity; Doxorubicin; Ferroptosis; Histamine; Histamine receptor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histamina / Ferroptosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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