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In vitro evaluation of zearalenone toxicity by comet assay.
Harcarova, M; Conkova, E; Kolenicova, S; Holeckova, B; Proskovcova, M.
Afiliación
  • Harcarova M; Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic.
  • Conkova E; Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic.
  • Kolenicova S; Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic.
  • Holeckova B; Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic.
  • Proskovcova M; Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic.
Pol J Vet Sci ; 25(3): 475-477, 2022 Sep.
Article en En | MEDLINE | ID: mdl-36156605
The aim of this study was to reveal the potentially genotoxic effect of zearalenone on bovine lymphocytes by comet assay in vitro. The bovine lymphocytes were exposed to various zearalenone concetrations (50; 10; 2; 0.4 and 0.08 ppm). The viability and DNA damage of lymphocytes was monitored after 2 h, 24 h, 48 h and 72 h. After 2 hours of zearalenone exposure, statistically significant DNA damage occurred at all tested concentrations of 0.08 ppm (12.2±1.25; p⟨0.05), 0.4 ppm (12.7±0.88; p⟨0.01), 2 ppm (12.0±0.51; p⟨0.01), 10 ppm (11.2±0.47; p⟨0.01) and at 50 ppm (14.2±0 61; p⟨0.001). Significantly greater DNA damage was also found after 24 h, 48 h and 72 h. The obtained results showed that zearalenone may induce DNA damage of the bovine lymphocytes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zearalenona Límite: Animals Idioma: En Revista: Pol J Vet Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zearalenona Límite: Animals Idioma: En Revista: Pol J Vet Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2022 Tipo del documento: Article Pais de publicación: Alemania