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3-MCPD as contaminant in processed foods: State of knowledge and remaining challenges.
Eisenreich, Andreas; Monien, Bernhard H; Götz, Mario E; Buhrke, Thorsten; Oberemm, Axel; Schultrich, Katharina; Abraham, Klaus; Braeuning, Albert; Schäfer, Bernd.
Afiliación
  • Eisenreich A; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address: andreas.eisenreich@bfr.bund.de.
  • Monien BH; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Götz ME; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Buhrke T; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Oberemm A; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Schultrich K; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Abraham K; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Braeuning A; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
  • Schäfer B; German Federal Institute for Risk Assessment (BfR), Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
Food Chem ; 403: 134332, 2023 Mar 01.
Article en En | MEDLINE | ID: mdl-36156403
3-Chloro-1,2-propanediol (3-MCPD) and its fatty acid esters (FE) are present as contaminants in different processed foods. Based on the available toxicological data the potential risk of 3-MCPD and its FE to human health was assessed by risk assessment authorities, including the European Food Safety Authority (EFSA). Considering the available data, EFSA concluded that 3-MCPD is a non-genotoxic compound exhibiting secondary carcinogenic effects in rodents. A tolerable daily intake of 2 µg/kg body weight and day was derived by EFSA for free and ester-bound 3-MCPD in 2018. However, there are still different pending issues that have remained unclear until now. Here, we summarize the current knowledge regarding 3-MCPD and its FE with a focus on pending issues regarding exposure assessment via biomarkers as well as the identification of (toxic) metabolites formed after exposure to FE of 3-MCPD and their modes of action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Clorhidrina Límite: Humans Idioma: En Revista: Food Chem Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Clorhidrina Límite: Humans Idioma: En Revista: Food Chem Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido