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A global phylogenomic and metabolic reconstruction of the large intestine bacterial community of domesticated cattle.
Teseo, S; Otani, S; Brinch, C; Leroy, S; Ruiz, P; Desvaux, M; Forano, E; Aarestrup, F M; Sapountzis, P.
Afiliación
  • Teseo S; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
  • Otani S; National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Brinch C; National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Leroy S; Université Clermont Auvergne, INRAE, UMR 0454 MEDIS, Clermont-Ferrand, France.
  • Ruiz P; Université Clermont Auvergne, INRAE, UMR 0454 MEDIS, Clermont-Ferrand, France.
  • Desvaux M; Université Clermont Auvergne, INRAE, UMR 0454 MEDIS, Clermont-Ferrand, France.
  • Forano E; Université Clermont Auvergne, INRAE, UMR 0454 MEDIS, Clermont-Ferrand, France.
  • Aarestrup FM; National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.
  • Sapountzis P; Université Clermont Auvergne, INRAE, UMR 0454 MEDIS, Clermont-Ferrand, France. panagiotis.sapountzis@inrae.fr.
Microbiome ; 10(1): 155, 2022 09 26.
Article en En | MEDLINE | ID: mdl-36155629
BACKGROUND: The large intestine is a colonization site of beneficial microbes complementing the nutrition of cattle but also of zoonotic and animal pathogens. Here, we present the first global gene catalog of cattle fecal microbiomes, a proxy of the large intestine microbiomes, from 436 metagenomes from six countries. RESULTS: Phylogenomics suggested that the reconstructed genomes and their close relatives form distinct branches and produced clustering patterns that were reminiscent of the metagenomics sample origin. Bacterial taxa had distinct metabolic profiles, and complete metabolic pathways were mainly linked to carbohydrates and amino acids metabolism. Dietary changes affected the community composition, diversity, and potential virulence. However, predicted enzymes, which were part of complete metabolic pathways, remained present, albeit encoded by different microbes. CONCLUSIONS: Our findings provide a global insight into the phylogenetic relationships and the metabolic potential of a rich yet understudied bacterial community and suggest that it provides valuable services to the host. However, we tentatively infer that members of that community are not irreplaceable, because similar to previous findings, symbionts of complex bacterial communities of mammals are expendable if there are substitutes that can perform the same task. Video Abstract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Metagenómica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Microbiome Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Metagenómica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Microbiome Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido