Acarbose Potentially Binds to the Type I Peptide Deformylase Catalytic Site and Inhibits Bacterial Growth: An <i>In Silico</i> and <i>In Vitro</i> Study.

Singh, Atul Kumar; Prajapati, Kumari Sunita; Kumar, Shashank

Acarbose Potentially Binds to the Type I Peptide Deformylase Catalytic Site and Inhibits Bacterial Growth: An In Silico and In Vitro Study.

Singh, Atul Kumar; Prajapati, Kumari Sunita; Kumar, Shashank.

Afiliación

Singh AK; Molecular Signaling & Drug Discovery Laboratory, Department of Biochemistry, Central University of Punjab, Bathinda, 151401, Punjab, India.
Prajapati KS; Molecular Signaling & Drug Discovery Laboratory, Department of Biochemistry, Central University of Punjab, Bathinda, 151401, Punjab, India.
Kumar S; Molecular Signaling & Drug Discovery Laboratory, Department of Biochemistry, Central University of Punjab, Bathinda, 151401, Punjab, India.

Curr Pharm Des ; 28(35): 2890-2900, 2022.

Article en En | MEDLINE | ID: mdl-36154601

Asunto(s)

Acarbosa; Escherichia coli; Humanos; Acarbosa/farmacología; Amidohidrolasas/química; Amidohidrolasas/metabolismo; Antibacterianos/farmacología; Antibacterianos/química; Dominio Catalítico; Inhibidores Enzimáticos/química; Escherichia coli/metabolismo; Simulación del Acoplamiento Molecular

Palabras clave

FDA-approved; Natural compound; acarbose; anti-bacterial; computational study; drug resistance; in vitro

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acarbosa / Escherichia coli Límite: Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos

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