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Circular RNA circ_0076631 promotes coxsackievirus B3 infection through modulating viral translation by sponging miR-214-3p.
Qin, Ying; Lin, Lexun; Yang, Shulong; Dai, Zongmao; Zhang, Congcong; Huang, Jingjing; Deng, Fengzhen; Yue, Xinxin; Ren, Long; Fei, Yanru; Zhao, Wenran; Wang, Yan; Zhong, Zhaohua.
Afiliación
  • Qin Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Lin L; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Yang S; Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Dai Z; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Zhang C; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Huang J; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Deng F; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Yue X; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Ren L; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China.
  • Fei Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Zhao W; Department of Cell Biology, Harbin Medical University, Harbin, China.
  • Wang Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Zhong Z; Department of Microbiology, Harbin Medical University, Harbin, China.
Front Microbiol ; 13: 975223, 2022.
Article en En | MEDLINE | ID: mdl-36147837
Coxsackievirus B (CVB), a member of Enterovirus genus of Picornaviridae, is the leading pathogen of viral myocarditis and dilated cardiomyopathy. The pathogenesis of CVB-induced myocarditis has not been completely elucidated, and no specific antiviral measurement is available presently. Circular RNAs (circRNAs) have been reported to be able to modulate viral replication and infection through bridging over non-coding RNAs (ncRNAs) and coding messenger RNAs (mRNAs). To date, the role of circRNAs in CVB infection is largely unknown. In this study, we found that hsa_circ_0076631 (circ_0076631) significantly promoted CVB type 3 (CVB3) replication. Further study showed that the underneath mechanism was circ_0076631 indirectly interacting with CVB3 through sponging miR-214-3p, which targeted the 3D-coding region of CVB3 genome to suppress viral translation. Knocking down circ-0076631 caused a suppression of CVB3 infection; thus, circ-0076631 may be a potential target for anti-CVB therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza