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Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients.
Palomino-Kobayashi, Luciano A; Ymaña, Barbara; Ruiz, Joaquim; Mayanga-Herrera, Ana; Ugarte-Gil, Manuel F; Pons, Maria J.
Afiliación
  • Palomino-Kobayashi LA; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru.
  • Ymaña B; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru.
  • Ruiz J; Grupo Enfermedades Infecciosas Emergentes. Universidad Científica del Sur, Lima, Peru.
  • Mayanga-Herrera A; Laboratorio de Cultivo Celular e Inmunología, Universidad Científica del Sur, Lima, Peru.
  • Ugarte-Gil MF; Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru.
  • Pons MJ; Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru.
Front Cell Infect Microbiol ; 12: 1000291, 2022.
Article en En | MEDLINE | ID: mdl-36147602
Zonulin has previously been related to intestinal permeability in various inflammatory diseases, and more recently to the physiopathology of severe COVID-19 infections. We analysed serum samples from a previous study of a Peruvian cohort of hospitalised COVID-19 patients, for the quantification of zonulin by sandwich ELISA. Comparisons with clinical data, haematological and biochemical parameters and cytokine/chemokine levels were made. We found higher baseline zonulin levels in deceased patients, and zonulin was associated with fatal outcome in multivariable analyses, even after adjustment for age, gender, and obesity. There were also positive correlations between zonulin, creatinine, D-dimer values and prothrombin time, while inverse correlations were found for Sa/FiO2 ratio and CCL5 (RANTES). Further longitudinal studies are recommended to analyse the variation of zonulin levels over time as well as their relationship with long-COVID.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Haptoglobinas / COVID-19 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Front Cell Infect Microbiol Año: 2022 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Haptoglobinas / COVID-19 Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Front Cell Infect Microbiol Año: 2022 Tipo del documento: Article País de afiliación: Perú Pais de publicación: Suiza