Downregulation of PPAR&#945; mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells.

Wu, Jingkui; Shao, Xinghua; Shen, Jianxiao; Lin, Qisheng; Zhu, Xuying; Li, Shu; Li, Jialin; Zhou, Wenyan; Qi, Chaojun; Ni, Zhaohui

Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells.

Wu, Jingkui; Shao, Xinghua; Shen, Jianxiao; Lin, Qisheng; Zhu, Xuying; Li, Shu; Li, Jialin; Zhou, Wenyan; Qi, Chaojun; Ni, Zhaohui.

Afiliación

Wu J; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shao X; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shen J; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lin Q; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhu X; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li S; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li J; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhou W; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qi C; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ni Z; Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Int J Biol Sci ; 18(14): 5438-5458, 2022.

Article en En | MEDLINE | ID: mdl-36147466

Asunto(s)

Proteínas de Unión a Ácidos Grasos; Ferroptosis; Glomerulonefritis por IGA; Albúminas/metabolismo; Creatinina; Regulación hacia Abajo/genética; Proteínas de Unión a Ácidos Grasos/genética; Proteínas de Unión a Ácidos Grasos/metabolismo; Glomerulonefritis por IGA/genética; Glomerulonefritis por IGA/metabolismo; Glutatión/metabolismo; Humanos; Inmunoglobulina A/genética; Inmunoglobulina A/metabolismo; Malondialdehído; Células Mesangiales/metabolismo; PPAR alfa/genética; PPAR alfa/metabolismo; ARN Interferente Pequeño; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Fatty acid binding protein 1; Ferroptosis; Human mesangial cells; Immunoglobulin A nephropathy; Peroxisome proliferator-activated receptor α; Weighted gene correlation network analysis

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión a Ácidos Grasos / Ferroptosis / Glomerulonefritis por IGA Límite: Humans Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google