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Cortical Auditory Evoked Potentials in Children with Prenatal Exposure to Zika Virus.
da Hora, Laís Cristine Delgado; Muniz, Lilian Ferreira; Venâncio, Leonardo Gleygson Angelo; Advíncula, Karina Paes; da Silva, Jéssica Dayane; de Albuquerque Britto, Diana Babini Lapa; de Barros Miranda Filho, Demócrito; Brickley, Elizabeth B; de Alencar Ximenes, Ricardo Arraes; da Silva Caldas Neto, Silvio; de Carvalho Leal, Mariana.
Afiliación
  • da Hora LCD; Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • Muniz LF; Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • Venâncio LGA; Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • Advíncula KP; Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • da Silva JD; Graduate, Program in Human Communication Health, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • de Albuquerque Britto DBL; Department of Speech, Language and Audiology, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
  • de Barros Miranda Filho D; Pós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
  • Brickley EB; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
  • de Alencar Ximenes RA; Pós-Graduação em Ciências da Saúde, Universidade de Pernambuco, Recife 50100-010, Brazil.
  • da Silva Caldas Neto S; Pós-Graduação em Medicina Tropical, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
  • de Carvalho Leal M; Department of Surgery, Universidade Federal de Pernambuco, Recife 50740-520, Brazil.
Viruses ; 14(9)2022 08 30.
Article en En | MEDLINE | ID: mdl-36146729
Prenatal exposure to ZIKV can cause neurologic and auditory damage. The electrophysiological responses obtained by Cortical Auditory Evoked Potentials (CAEP) may provide an objective method to investigate the function of cortical auditory pathways in children exposed to ZIKV. This case series analyzed the findings of CAEP in prenatal-period ZIKV-exposed children with and without microcephaly. The CAEP was performed in a total of 24 children. Five magnetic resonance imaging (MRI) images of the inner ear and brain of microcephalic children were analyzed and compared with CAEP measurements. Ventriculomegaly (80%), cortical/subcortical calcification (80%), and brain reduction (60%) were the most common alterations in the MRI. The P1-N1-P2 complex of the CAEP was observed in all children evaluated. The peak N2 was absent in two children. In the comparison of the CAEP measurements between the groups, children with microcephaly presented a higher amplitude of P2 (p = 0.017), which may reflect immaturity of the auditory pathways. Microcephalic and normocephalic children with prenatal exposure to ZIKV presented with the mandatory components of the CAEPs, regardless of changes in the CNS, suggesting that this population has, to some extent, the cortical ability to process sound stimuli preserved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Virus Zika / Infección por el Virus Zika / Microcefalia Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Virus Zika / Infección por el Virus Zika / Microcefalia Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Viruses Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza