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A Novel C@Fe@Cu Nanocomposite Loaded with Doxorubicin Tailored for the Treatment of Hepatocellular Carcinoma.
Saddik, Mohammed S; Elsayed, Mahmoud M A; Abdel-Rheem, Amany A; El-Mokhtar, Mohamed A; Mosa, Eisa S; Al-Hakkani, Mostafa F; Al-Shelkamy, Samah A; Khames, Ali; Daha, Mohamed A; Abdel-Aleem, Jelan A.
Afiliación
  • Saddik MS; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
  • Elsayed MMA; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
  • Abdel-Rheem AA; Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
  • El-Mokhtar MA; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
  • Mosa ES; Mining, Metallurgy and Petroleum Engineering Department, Al-Azhar University, Nasr City, Cairo 11371, Egypt.
  • Al-Hakkani MF; Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
  • Al-Shelkamy SA; Department of Physics, Faculty of Science, New Valley University, El-Kharja 72511, Egypt.
  • Khames A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.
  • Daha MA; Production Engineering Department, Faculty of Engineering, Alexandria University, El-Chatby, Alexandria 21544, Egypt.
  • Abdel-Aleem JA; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt.
Pharmaceutics ; 14(9)2022 Sep 01.
Article en En | MEDLINE | ID: mdl-36145592
High mortality and morbidity rates are related to hepatocellular carcinoma (HCC), which is the most prevalent type of liver cancer. A new vision for cancer treatment and cancer cell targeting has emerged with the application of nanotechnology, which reduces the systemic toxicity and adverse effects of chemotherapy medications while increasing their effectiveness. It was the goal of the proposed work to create and investigate an anticancer C@Fe@Cu nanocomposite (NC) loaded with Doxorubicin (DOX) for the treatment of HCC. Scanning and transmission electron microscopes (SEM and TEM) were used to examine the morphology of the produced NC. The formulation variables (DOX content, C@Fe@Cu NC weight, and stirring speed) were analyzed and optimized using Box-Behnken Design (BBD) and Response Surface Methodology (RSM). Additionally, X-ray diffraction patterns (XRD) and Fourier Transform Infrared (FTIR) were investigated. Doxorubicin and DOX- loaded C@Fe@Cu NC (DOX-C@Fe@Cu NC) were also assessed against HEPG2 cells for anticancer efficacy (Hepatic cancer cell line). The results revealed the formation of C@Fe@Cu NC with a mean size of 7.8 nm. A D-R model with a mean size of 24.1 nm best fits the adsorption behavior of DOX onto the C@Fe@Cu NC surface. DOX-C@Fe@Cu NC has also been demonstrated to have a considerably lower IC50 and higher cytotoxicity than DOX alone in an in vitro investigation. Therefore, DOX-C@Fe@Cu NC is a promising DOX delivery vehicle for the full recovery of HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmaceutics Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Suiza