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The Impact of Ethnicity on Fetal and Maternal Outcomes of Gestational Diabetes.
Filardi, Tiziana; Gentile, Maria Cristina; Venditti, Vittorio; Valente, Antonella; Bleve, Enrico; Santangelo, Carmela; Morano, Susanna.
Afiliación
  • Filardi T; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
  • Gentile MC; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
  • Venditti V; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
  • Valente A; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
  • Bleve E; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
  • Santangelo C; Center for Gender-Specific Medicine, Gender Specific Prevention and Health Unit, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • Morano S; Department of Experimental Medicine, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
Medicina (Kaunas) ; 58(9)2022 Aug 25.
Article en En | MEDLINE | ID: mdl-36143838
Background and Objectives: The prevalence of gestational diabetes mellitus (GDM) significantly varies across different ethnic groups. In particular, Africans, Latinos, Asians and Pacific Islanders are the ethnic groups with the highest risk of GDM. The aim of this study was to evaluate the impact of ethnicity on pregnancy outcomes in GDM. Patients and Methods: n = 399 patients with GDM were enrolled, n = 76 patients of high-risk ethnicity (HR-GDM), and n = 323 of low-risk ethnicity (LR-GDM). Clinical and biochemical parameters were collected during pregnancy until delivery. Fetal and maternal short-term outcomes were evaluated. Results: HR-GDM had significantly higher values of glycosylated hemoglobin checked at 26−29 weeks of gestation (p < 0.001). Gestational age at delivery was significantly lower in HR-GDM (p = 0.03). The prevalence of impaired fetal growth was significantly higher in HR-GDM than LR-GDM (p = 0.009). In logistic regression analysis, the likelihood of impaired fetal growth was seven times higher in HR-GDM than in LR-GDM, after adjustment for pre-pregnancy BMI and gestational weight gain (OR = 7.1 [2.0−25.7] 95% CI, p = 0.003). Conclusions: HR-GDM had worse pregnancy outcomes compared with LR-GDM. An ethnicity-tailored clinical approach might be effective in reducing adverse outcomes in GDM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional / Ganancia de Peso Gestacional Tipo de estudio: Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Pregnancy Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional / Ganancia de Peso Gestacional Tipo de estudio: Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Pregnancy Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza