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Microbiota Assessment of Pediatric Simple and Complex Acute Appendicitis.
Kakar, Mohit; Reinis, Aigars; Kroica, Juta; Engelis, Arnis; Broks, Renars; Asare, Lasma; Vermeulen, Marelize; Senica, Simone Oliver; Saxena, Amulya; Petersons, Aigars.
Afiliación
  • Kakar M; Department of Pediatric Surgery, Children's Clinical University Hospital, LV-1004 Riga, Latvia.
  • Reinis A; Department of Pediatric Surgery, Riga Stradins University, LV-1007 Riga, Latvia.
  • Kroica J; Department of Biology and Microbiology, Riga Stradins University, LV-1007 Riga, Latvia.
  • Engelis A; Department of Biology and Microbiology, Riga Stradins University, LV-1007 Riga, Latvia.
  • Broks R; Department of Pediatric Surgery, Children's Clinical University Hospital, LV-1004 Riga, Latvia.
  • Asare L; Department of Pediatric Surgery, Riga Stradins University, LV-1007 Riga, Latvia.
  • Vermeulen M; Department of Biology and Microbiology, Riga Stradins University, LV-1007 Riga, Latvia.
  • Senica SO; Statistics Unit, Riga Stradins University, LV-1046 Riga, Latvia.
  • Saxena A; Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia.
  • Petersons A; Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia.
Medicina (Kaunas) ; 58(9)2022 Aug 23.
Article en En | MEDLINE | ID: mdl-36143821
Background and Objectives. The aim of this study is to determine the prevailing microbiota in samples from pediatric patients with acute appendicitis, as well as evaluate the antibacterial sensitivity of the isolated microorganisms, comparing the data obtained with the clinic's antibacterial therapy guidelines. Materials and Methods. The study group consisted of 93 patients between the ages of 7 and 18. All patients underwent a laparoscopic or conventional appendectomy. The children were hospitalized with signs and symptoms suggestive of acute appendicitis. Microbiological cultures from the appendix and abdominal cavity were collected intraoperatively. Results. E. coli was identified in most cases irrespective of the clinical presentation of acute appendicitis. Most strains were susceptible to ampicillin and amoxicillin/clavulanic acid. Five strains of E. coli produced extended spectrum beta-lactamase (ESBL). Pseudomonas aeruginosa (P. aeruginosa) was the second most commonly isolated causative agent. Furthermore, it was common in cases of acute complex appendicitis. Most strains of P. aeruginosa were resistant to amoxicillin/clavulanic acid, ertapenem, ampicillin and cefotaxime, yet were susceptible to ceftazidime. Regardless of the clinical presentation, the samples yielded mixed isolates. Conclusion. E. coli is the main causative agent of acute appendicitis in the pediatric population displaying susceptibility to various antibiotics. P. aeruginosa was more prevalent in cases of acute complex appendicitis. P. aeruginosa isolates were susceptible to ceftazidime; however, they were resistant to cefotaxime, which should, therefore, be removed from guidelines for empirical antibacterial treatment of acute appendicitis due to phenotypic resistance of P. aeruginosa. We recommend antibiotics with distinct implementation to avoid antibiotic resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apendicitis / Microbiota Tipo de estudio: Guideline Límite: Adolescent / Child / Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apendicitis / Microbiota Tipo de estudio: Guideline Límite: Adolescent / Child / Humans Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Letonia Pais de publicación: Suiza