Forces Driving a Magic Bullet to Its Target: Revisiting the Role of Thermodynamics in Drug Design, Development, and Optimization.

Minetti, Conceição A; Remeta, David P

Minetti, Conceição A; Remeta, David P.

Afiliación

Minetti CA; Department of Chemistry and Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA.
Remeta DP; Department of Chemistry and Chemical Biology, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA.

Life (Basel) ; 12(9)2022 Sep 15.

Article en En | MEDLINE | ID: mdl-36143474

Palabras clave

drug discovery; drug-like properties; drug-target interactions; enthalpic efficiency; fragment-based drug discovery; group efficiency; isothermal titration calorimetry; lead optimization; lipophilic efficiency; thermodynamic binding signatures

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Life (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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