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Genetic Association of Beta-Myosin Heavy-Chain Gene (MYH7) with Cardiac Dysfunction.
Yousaf, Memoona; Khan, Waqas Ahmed; Shahzad, Khurrum; Khan, Haq Nawaz; Ali, Basharat; Hussain, Misbah; Awan, Fazli Rabbi; Mustafa, Hamid; Sheikh, Farah Nadia.
Afiliación
  • Yousaf M; Department of Biotechnology, University of Sargodha, Sargodha 40100, Pakistan.
  • Khan WA; Department of Biotechnology, University of Sargodha, Sargodha 40100, Pakistan.
  • Shahzad K; Department of Biotechnology, University of Sargodha, Sargodha 40100, Pakistan.
  • Khan HN; Institute of Clinical Chemistry, University Hospital Leipzig Institute of Clinical Chemistry Liebigstraße27, D-04103 Leipzig, Germany.
  • Ali B; Diabetes and Cardio-Metabolic Disorders Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
  • Hussain M; Department of Family Medicine, University of Health Sciences, Lahore 42000, Pakistan.
  • Awan FR; Department of Biotechnology, University of Sargodha, Sargodha 40100, Pakistan.
  • Mustafa H; Diabetes and Cardio-Metabolic Disorders Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
  • Sheikh FN; Diabetes and Cardio-Metabolic Disorders Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
Genes (Basel) ; 13(9)2022 08 29.
Article en En | MEDLINE | ID: mdl-36140722
Cardiac dysfunction accelerates the risk of heart failure, and its pathogenesis involves a complex interaction between genetic and environmental factors. Variations in myosin affect contractile abilities of cardiomyocytes and cause structural and functional abnormalities in myocardium. The study aims to find the association of MYH7 rs121913642 (c.1594 T>C) and rs121913645 (c.667G>A) variants with cardiac dysfunction in the Punjabi Pakistani population. Patients with heart failure (n = 232) and healthy controls (n = 205) were enrolled in this study. MYH7 variant genotyping was performed using tetra ARMS-PCR. MYH7 rs121913642 TC genotype was significantly more prevalent in the patient group (p < 0.001). However, MYH7 rs121913645 genotype frequencies were not significantly different between the patient and control groups (p < 0.666). Regression analysis also revealed that the rs121913642 C allele increases the risk of cardiac failure by ~2 [OR:1.98, CI: 1.31−2.98, p < 0.001] in comparison to the T allele. High levels of the cardiac enzymes cardiac troponin I (cTnI) and CK-MB were observed in patients. There was also an increase in total cholesterol, LDL cholesterol, and uric acid in patients compared to the healthy control group (p < 0.001). In conclusion, the MYH7 gene variant rs121913642 is genetically associated with cardiac dysfunction and involved in the pathogenesis of HF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadenas Pesadas de Miosina / Cardiopatías / Insuficiencia Cardíaca Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadenas Pesadas de Miosina / Cardiopatías / Insuficiencia Cardíaca Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Genes (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza