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Clinical characteristics and differential cytokine expression in hospitalized Taiwanese children with respiratory syncytial virus and rhinovirus bronchiolitis.
Lee, Chun Yi; Sung, Chia Hsin; Wu, Meng Che; Chang, Yu Chuan; Chang, Jih Chin; Fang, Yu Ping; Wang, Nancy M; Chou, Teh Ying; Chan, Yu Jiun.
Afiliación
  • Lee CY; Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Sung CH; Department of Clinical Laboratory, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
  • Wu MC; Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
  • Chang YC; Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
  • Chang JC; Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
  • Fang YP; Department of Pediatrics, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
  • Wang NM; Department of Biology, National Changhua University of Education, Changhua, Taiwan.
  • Chou TY; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: tychou@vghtpe.gov.tw.
  • Chan YJ; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming Chao-Tung University, ShinTzu, Taiwan. Electronic address: yjchan@vghtpe.gov.tw.
J Microbiol Immunol Infect ; 56(2): 282-291, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36137923
BACKGROUND: Viral bronchiolitis presents a heterogeneous spectrum. In this study, we investigated the clinical characteristics and the cytokines/chemokines profiles among respiratory syncytial virus (RSV), rhinovirus (RV), and their dual infection in Taiwanese children with viral bronchiolitis. METHOD: This study was conducted between October 2014 and June 2017. Viral etiology was identified using a Luminex respiratory virus panel and blood cytokines were evaluated using a MILLIPLEX MAP Human Cytokine/Chemokine Panel. Cytokine/Chemokine expressions were compared by clinical severity, steroid treatment, and viral entities. RESULTS: A total of 184 patients were evaluated; at least one respiratory virus was identified in 163 (88.6%) patients. RSV and RV were the two leading viral etiologies, with 25.5% and 17.3%, respectively. RV bronchiolitis has a comparable severity to RSV but is more common in children of an older age with a history of recurrent wheezing and blood eosinophilia. Decreased tumor necrosis factor-alpha (TNF-α) and interferon gamma (INF-γ) levels were correlated with clinical severity. Patients infected with RV exhibited higher levels of Interleukin (IL)-22, IL-23, IL-25, IL-31, and IL-33 (p < 0.05), whereas those with RSV had higher levels of TNF-α, INF-γ, and IL-10 (p < 0.05). Systemic steroid treatment was associated with higher expressions of IL-4, IL-8, IL-13, and MIP-1α levels (p < 0.05). Cluster analysis revealed a high correlation of IL-33 and IL-31(R2 = 0.9731, p < 0.0001). CONCLUSION: Different viral infections elicited the characteristic clinical presentation and immune profiles in bronchiolitis. Our findings also highlight the role of the IL-33/IL-31 axis in the immunopathogenesis of bronchiolitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiolitis / Bronquiolitis Viral / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Prognostic_studies Límite: Child / Humans / Infant Idioma: En Revista: J Microbiol Immunol Infect Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bronquiolitis / Bronquiolitis Viral / Virus Sincitial Respiratorio Humano / Infecciones por Virus Sincitial Respiratorio Tipo de estudio: Prognostic_studies Límite: Child / Humans / Infant Idioma: En Revista: J Microbiol Immunol Infect Asunto de la revista: ALERGIA E IMUNOLOGIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido