Construction of Heterobiaryl Skeletons through Pd-Catalyzed Cross-Coupling of Nitroarenes and Heterocyclic Arylborononate Esters with a Sterically Demanding NHC Ligand.

Chen, Wei; Chen, Wanzhi; Liu, Miaochang; Wu, Huayue

Chen, Wei; Chen, Wanzhi; Liu, Miaochang; Wu, Huayue.

Afiliación

Chen W; Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China.
Chen W; Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China.
Liu M; College of Chemistry and Materials Engineering, Wenzhou University, 588 New Chaoyang Street, Wenzhou 325027, China.
Wu H; College of Chemistry and Materials Engineering, Wenzhou University, 588 New Chaoyang Street, Wenzhou 325027, China.

Org Lett ; 24(38): 6983-6987, 2022 Sep 30.

Article en En | MEDLINE | ID: mdl-36135327

RESUMEN

The palladium-catalyzed Suzuki-Miyaura cross-couplings of nitroarenes and heteroarylboronate esters has been developed. A number of heterobiaryl compounds containing pyridine, pyrimidine, quinoline, furan, thiophene, and pyrazole were prepared using [Pd(cinnamyl)Cl]2/2-aryl-5-(2,4,6-triisopropylphenyl)-2,3-imidazolylidene[1,5-a]pyridines as the catalysts in good to excellent yields. The synthetic practicality of this approach is demonstrated through the synthesis of druglike molecules.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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