Tuneable manganese oxide nanoparticle based theranostic agents for potential diagnosis and drug delivery.

Poon, Kingsley; Lu, Zufu; De Deene, Yves; Ramaswamy, Yogambha; Zreiqat, Hala; Singh, Gurvinder

Poon, Kingsley; Lu, Zufu; De Deene, Yves; Ramaswamy, Yogambha; Zreiqat, Hala; Singh, Gurvinder.

Afiliación

Poon K; ARC Centre for Innovative BioEngineering, Tissue Engineering and Biomaterials Research Unit, Sydney Nano Institute, School of Biomedical Engineering, The University of Sydney NSW 2008 Australia hala.zreiqat@sydney.edu.au gurvinder.singh@sydney.edu.au.
Lu Z; ARC Centre for Innovative BioEngineering, Tissue Engineering and Biomaterials Research Unit, Sydney Nano Institute, School of Biomedical Engineering, The University of Sydney NSW 2008 Australia hala.zreiqat@sydney.edu.au gurvinder.singh@sydney.edu.au.
De Deene Y; Department of Engineering, The Biomedical Engineering Laboratory, Macquarie University Sydney 2109 Australia.
Ramaswamy Y; ARC Centre for Innovative BioEngineering, Tissue Engineering and Biomaterials Research Unit, Sydney Nano Institute, School of Biomedical Engineering, The University of Sydney NSW 2008 Australia hala.zreiqat@sydney.edu.au gurvinder.singh@sydney.edu.au.
Zreiqat H; ARC Centre for Innovative BioEngineering, Tissue Engineering and Biomaterials Research Unit, Sydney Nano Institute, School of Biomedical Engineering, The University of Sydney NSW 2008 Australia hala.zreiqat@sydney.edu.au gurvinder.singh@sydney.edu.au.
Singh G; ARC Centre for Innovative BioEngineering, Tissue Engineering and Biomaterials Research Unit, Sydney Nano Institute, School of Biomedical Engineering, The University of Sydney NSW 2008 Australia hala.zreiqat@sydney.edu.au gurvinder.singh@sydney.edu.au.

Nanoscale Adv ; 3(14): 4052-4061, 2021 Jul 13.

Article en En | MEDLINE | ID: mdl-36132835

RESUMEN

Among various magnetic nanoparticles, manganese oxide nanoparticles are considered as established T 1 magnetic resonance imaging (MRI) contrast agents for preclinical research. The implications of their degradation properties and use as therapeutic carriers in drug delivery systems have not been explored. In addition, how the chemical composition and size of manganese oxide nanoparticles, as well as the surrounding environment, influence their degradation and MRI contrast properties (T 1 vs. T 2) have not been studied in great detail. A fundamental understanding of their characteristic properties, such as degradation, is highly desirable for developing simultaneous diagnosis and therapeutic solutions. Here, we demonstrate how the precursor type and reaction environment affect the size and chemical composition of manganese oxide nanoparticles and evaluate their influence on the nanoparticle degradability and release of the drug l-3,4-dihydroxyphenylalanine (l-dopa). The results show that the degradation rate (and the associated release of drug l-dopa molecules) of manganese oxide nanoparticles depends on their size, composition and the surrounding environment (aqueous or biometric fluid). The dependence of MRI relaxivities of manganese oxide nanoparticles on the size, chemical composition and nanoparticle degradation in water is also established. A preliminary cell viability study reveals the cytocompatible properties of l-dopa functionalized manganese oxide nanoparticles. Overall, this work provides new insights into smartly designed manganese oxide nanoparticles with multitasking capabilities to target bioimaging and therapeutic applications.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Nanoscale Adv Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

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