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Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells.
Gigliotti, Casimiro Luca; Boggio, Elena; Favero, Francesco; Incarnato, Danny; Santoro, Claudio; Oliviero, Salvatore; Rojo, Josè Maria; Zucchelli, Silvia; Persichetti, Francesca; Baldanzi, Gianluca; Dianzani, Umberto; Corà, Davide.
Afiliación
  • Gigliotti CL; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Boggio E; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
  • Favero F; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Incarnato D; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
  • Santoro C; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Oliviero S; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
  • Rojo JM; CAAD - Center for Translational Research on Autoimmune and Allergic Disease, Novara, Italy.
  • Zucchelli S; Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, Netherlands.
  • Persichetti F; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Baldanzi G; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
  • Dianzani U; CAAD - Center for Translational Research on Autoimmune and Allergic Disease, Novara, Italy.
  • Corà D; Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università di Torino, Torino, Italy.
Front Immunol ; 13: 915963, 2022.
Article en En | MEDLINE | ID: mdl-36131938
Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have been demonstrated for each family member, the specific signaling pathways differentiating ICOS- from CD28-mediated costimulation during early T-cell activation are poorly characterized. In the present study, we have performed RNA-Seq-based global transcriptome profiling of anti-CD3-treated naïve CD4+ T cells upon costimulation through either inducible costimulator (ICOS) or CD28, revealing a set of signaling pathways specifically associated with each signal. In particular, we show that CD3/ICOS costimulation plays a major role in pathways related to STAT3 function and osteoarthritis (OA), whereas the CD3/CD28 axis mainly regulates p38 MAPK signaling. Furthermore, we report the activation of distinct immunometabolic pathways, with CD3/ICOS costimulation preferentially targeting glycosaminoglycans (GAGs) and CD3/CD28 regulating mitochondrial respiratory chain and cholesterol biosynthesis. These data suggest that ICOS and CD28 costimulatory signals play distinct roles during the activation of naïve T cells by modulating distinct sets of immunological and immunometabolic genes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Antígenos CD28 Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Antígenos CD28 Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza