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Nasopharyngeal Carriage of Pneumococcus in Children in England up to 10 Years After 13-Valent Pneumococcal Conjugate Vaccine Introduction: Persistence of Serotypes 3 and 19A and Emergence of 7C.
Tiley, Karen S; Ratcliffe, Helen; Voysey, Merryn; Jefferies, Kimberley; Sinclair, Gemma; Carr, Melanie; Colin-Jones, Rachel; Smith, David; Bowman, Jaclyn; Hart, Thomas; Kandasamy, Rama; Hinds, Jason; Gould, Katherine; Berbers, Guy; Tcherniaeva, Irina; Robinson, Hannah; Plested, Emma; Aley, Parvinder; Snape, Matthew D.
Afiliación
  • Tiley KS; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Ratcliffe H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Jefferies K; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Sinclair G; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Carr M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Colin-Jones R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Smith D; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Bowman J; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Hart T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Kandasamy R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Hinds J; Institute for Infection and Immunity, St George's University, London, United Kingdom.
  • Gould K; BUGS Bioscience, London Bioscience Innovation Centre, London, United Kingdom.
  • Berbers G; Institute for Infection and Immunity, St George's University, London, United Kingdom.
  • Tcherniaeva I; BUGS Bioscience, London Bioscience Innovation Centre, London, United Kingdom.
  • Robinson H; Immunology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Plested E; Immunology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Aley P; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Snape MD; National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom, and.
J Infect Dis ; 227(5): 610-621, 2023 03 01.
Article en En | MEDLINE | ID: mdl-36130327
BACKGROUND: Monitoring changes in pharyngeal carriage of pneumococcus in children following 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the United Kingdom in 2010 informs understanding of patterns of invasive pneumococcal disease (IPD) incidence. METHODS: Nasopharyngeal swabs from healthy children vaccinated with PCV13 according to schedule (2, 4, and 12 months) were cultured and serotyped. Results for children aged 13-48 months were compared between 2014-2015 and 2017-2019 and with children aged 6-12 months (2017-2020). Blood was obtained from a subset of children for pneumococcal serotype-specific immunoglobulin G (IgG). RESULTS: Total pneumococcal carriage at 13-48 months was 47.9% (473/988) in 2014-2015 and 51.8% (412/795) in 2017-2019 (P = .10); at age 6-12 months this value was 44.6% (274/615). In 2017-2019, 2.9% (95% confidence interval, 1.8%-4.3%) of children aged 13-48 months carried PCV13 serotypes (mainly 3 [1.5%] and 19A [0.8%]) and >20% carried the additional 20-valent PCV (PCV20) serotypes. Similar proportions of children had IgG ≥0.35 IU/mL for each serotype in 2014-2015 and 2017-2019. Serotype 7C carriage increased significantly (P < .01) between 2014-2015 and 2017-2019. Carriage of PCV20 serotypes 8 and 12F, both major causes of IPD, was rare. CONCLUSIONS: Introduction of PCV20, if licensed for children, could significantly change the composition of pneumococcal serotypes carried in the pharynx of UK children. CLINICAL TRIALS REGISTRATION: NCT03102840.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae Límite: Child / Humans / Infant País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae Límite: Child / Humans / Infant País/Región como asunto: Europa Idioma: En Revista: J Infect Dis Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos