A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors.

Das, Bhaskar C; Yadav, Pratik; Das, Sasmita; He, John Cijiang

Das, Bhaskar C; Yadav, Pratik; Das, Sasmita; He, John Cijiang.

Afiliación

Das BC; Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Brooklyn NY 11201 USA Bhaskar.Das@liu.edu.
Yadav P; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai New York NY 10029 USA.
Das S; Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Brooklyn NY 11201 USA Bhaskar.Das@liu.edu.
He JC; Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University Brooklyn NY 11201 USA Bhaskar.Das@liu.edu.

RSC Adv ; 12(37): 24187-24191, 2022 Aug 22.

Article en En | MEDLINE | ID: mdl-36128533

RESUMEN

Herein, we demonstrate a Pd catalyzed C-4 borylation of structurally complex chloroquinolines with bis(pinacolato)diboron under relatively simple and efficient conditions. Moreover, the borylated quinolines were converted into oxaborole, trifluoroborate salt and boronic acid and also rendered in the Suzuki reaction successfully. The method was also applied for the synthesis of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors. The strategy opens up new avenues for the functionalization of quinolines as potential probes and pharmacological agents for future biomedical research.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: RSC Adv Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

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