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Dynamics of SARS-CoV-2 exposure in Malawian infants between February 2020 and May 2021.
Baroncelli, Silvia; Galluzzo, Clementina Maria; Orlando, Stefano; Mphwere, Robert; Kavalo, Thom; Luhanga, Richard; Amici, Roberta; Floridia, Marco; Andreotti, Mauro; Scarcella, Paola; Marazzi, Maria Cristina; Giuliano, Marina.
Afiliación
  • Baroncelli S; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • Galluzzo CM; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • Orlando S; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Mphwere R; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi.
  • Kavalo T; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi.
  • Luhanga R; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi.
  • Amici R; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • Floridia M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • Andreotti M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • Scarcella P; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
  • Marazzi MC; Department of Human Sciences, LUMSA University, Borgo S. Angelo 13, 00193 Rome, Italy.
  • Giuliano M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
J Clin Virol Plus ; 2(4): 100110, 2022 Nov.
Article en En | MEDLINE | ID: mdl-36128323
Background: Very limited information is available on SARS-CoV-2 seroprevalence in infants in sub-Saharan countries. Objective: In this study, we aimed to determine the rate and the temporal evolution of SARS CoV-2 seropositivity in breastfed Malawian infants. Study design: Blood samples (n = 250) from 158 infants, born to HIV-negative women and women living with HIV, collected from February 2020 to May 2021, were first tested using an Anti-IgG/A/M SARS CoV 2 ELISA assay against trimeric spike protein, and then, if positive, confirmed using a second ELISA assay detecting IgG against Receptor Binding Domain. Results: The confirmed prevalence of anti-SARS CoV-2 antibodies was 31.0% (95% CI: 23.7%-38.3%) with no significant difference between HIV-exposed and HIV-unexposed infants (29.3% and 37.1% respectively, P = 0.410). The presence of anti-SARS-CoV-2 IgG was not associated with maternal socioeconomic or demographic indices. Conclusions: Our data underline the wide spread of the SARS-CoV-2 infection in the pediatric population in sub-Saharan Africa. Design of more specific serological tests for African samples and improvements in serosurveillance programs are needed for more rigorous monitoring of the dynamics of SARS-CoV-2 infection in Africa.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Clin Virol Plus Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Clin Virol Plus Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido