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The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer.
Usher-Smith, Juliet A; Godoy, Angela; Burge, Sarah W; Burbidge, Simon; Cartledge, Jon; Crosbie, Philip A J; Eckert, Claire; Farquhar, Fiona; Hammond, David; Hancock, Neil; Iball, Gareth R; Kimuli, Michael; Masson, Golnessa; Neal, Richard D; Rogerson, Suzanne; Rossi, Sabrina H; Sala, Evis; Smith, Andrew; Sharp, Stephen J; Simmonds, Irene; Wallace, Tom; Ward, Matthew; Callister, Matthew E J; Stewart, Grant D.
Afiliación
  • Usher-Smith JA; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Godoy A; Department of Surgery, University of Cambridge, Cambridge, UK.
  • Burge SW; Department of Oncology, University of Cambridge, Cambridge, UK.
  • Burbidge S; Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
  • Cartledge J; Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
  • Crosbie PAJ; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
  • Eckert C; Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
  • Farquhar F; Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Hammond D; Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Hancock N; Leeds Diagnosis & Screening Unit, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
  • Iball GR; Department of Medical Physics & Engineering, Leeds teaching hospitals NHS Trust, Leeds, UK.
  • Kimuli M; Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK.
  • Masson G; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Neal RD; Pitcairn Practice, Balmullo Surgery, Fife, UK.
  • Rogerson S; College of Medicine and Health, University of Exeter, Exeter, UK.
  • Rossi SH; Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Sala E; Department of Surgery, University of Cambridge, Cambridge, UK.
  • Smith A; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Sharp SJ; Department of Radiology, Catholic University Sacro Cuore and Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
  • Simmonds I; Upper Gastro-intestinal and Pancreas Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Wallace T; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Ward M; Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
  • Callister MEJ; Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • Stewart GD; Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK.
BMJ Open ; 12(9): e063018, 2022 09 20.
Article en En | MEDLINE | ID: mdl-36127097
INTRODUCTION: Kidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening programme for RCC. The Yorkshire Kidney Screening Trial (YKST) will assess the feasibility of adding non-contrast abdominal CT scanning to screen for RCC and other abdominal pathology within the Yorkshire Lung Screening Trial (YLST), a randomised trial of community-based CT screening for lung cancer. METHODS AND ANALYSIS: In YLST, ever-smokers aged 55-80 years registered with a general practice in Leeds have been randomised to a Lung Health Check assessment, including a thoracic low-dose CT (LDCT) for those at high risk of lung cancer, or routine care. YLST participants randomised to the Lung Health Check arm who attend for the second round of screening at 2 years without a history of RCC or abdominal CT scan within the previous 6 months will be invited to take part in YKST. We anticipate inviting 4700 participants. Those who consent will have an abdominal CT immediately following their YLST thoracic LDCT. A subset of participants and the healthcare workers involved will be invited to take part in a qualitative interview. Primary objectives are to quantify the uptake of the abdominal CT, assess the acceptability of the combined screening approach and pilot the majority of procedures for a subsequent randomised controlled trial of RCC screening within lung cancer screening. ETHICS AND DISSEMINATION: YKST was approved by the North West-Preston Research Ethics Committee (21/NW/0021), and the Health Research Authority on 3 February 2021. Trial results will be disseminated at clinical meetings, in peer-reviewed journals and to policy-makers. Findings will be made available to participants via the study website (www.YKST.org). TRIAL REGISTRATION NUMBERS: NCT05005195 and ISRCTN18055040.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Diagnostic_studies / Qualitative_research / Screening_studies Aspecto: Ethics Límite: Humans Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Diagnostic_studies / Qualitative_research / Screening_studies Aspecto: Ethics Límite: Humans Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido