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Prospective Surveillance with Compression for Subclinical Lymphedema: Symptoms, Skin, and Quality-of-Life Outcomes.
Dietrich, Mary S; Gaitatzis, Katrina; Koelmeyer, Louise; Boyages, John; Abramson, Vandana G; McLaughlin, Sarah A; Ngui, Nicholas; Elder, Elisabeth; French, James; Hsu, Jeremy; Hughes, T Michael; Stolldorf, Deonni P; Shah, Chirag; Ridner, Sheila H.
Afiliación
  • Dietrich MS; Vanderbilt University School of Nursing, Nashville, Tennessee, USA.
  • Gaitatzis K; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Koelmeyer L; Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia.
  • Boyages J; Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia.
  • Abramson VG; Australian Lymphoedema Education, Research, and Treatment (ALERT) Program, Department of Health Sciences, Macquarie University Macquarie Park, Sydney, Australia.
  • McLaughlin SA; Sydney Adventist Hospital Integrated Cancer Centre, ICON Cancer Centre, Wahroonga, Australia.
  • Ngui N; Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
  • Elder E; Mayo Clinic, Jacksonville, Florida, USA.
  • French J; Northern Surgical Oncology, Sydney Adventist Hospital, Wahroonga, Australia.
  • Hsu J; Westmead Breast Cancer Center Institute, Westmead Hospital, Westmead, Australia.
  • Hughes TM; Department of Surgery, The University of Sydney, Sydney, Australia.
  • Stolldorf DP; Lakeside Specialist Breast Clinic, Lakeview Private Hospital Norwest, Norwest, Australia.
  • Shah C; Westmead Breast Cancer Center Institute, Westmead Hospital, Westmead, Australia.
  • Ridner SH; Department of Surgery, The University of Sydney, Sydney, Australia.
Lymphat Res Biol ; 21(3): 304-313, 2023 06.
Article en En | MEDLINE | ID: mdl-36126315
Background: Patients underwent a compression (sleeve and gauntlet) intervention for subclinical breast cancer-related lymphedema (S-BCRL). Physical, emotional, and quality-of-life (QoL) outcomes were examined. Associations of change in extracellular fluid alone through bioimpedance spectroscopy (BIS) or change in whole-arm volume through tape measure with the outcomes at time of S-BCRL were explored. Methods and Results: We enrolled newly diagnosed nonmetastatic breast cancer patients for surveillance up to 36 months postoperatively. Upon detection of S-BCRL, a 28-day compression intervention was initiated. Data were obtained through physical examination/measurement and self-report instruments: skin examination, Lymphedema Symptom Intensity and Distress Survey-Arm, and Functional Assessment of Cancer Therapy General (FACT-G), Breast (FACT-B), and FACT-B+4. Improvements with intervention were observed in the proportion of patients reporting symptom scores ≥3 in function (Cohen's d = -0.46, p < 0.01), in biobehavioral (Cohen's d = -0.30, p < 0.05), maximum number of skin conditions (Cohen's d = -0.34, p < 0.05. 3), FACT-B (Cohen's d = 0.52, p < 0.01), and FACT-B + four (Cohen's d = -0.42, p < 0.01). At the study endpoint, compared with those who did not progress, chronic breast cancer-related lymphedema (C-BCRL) progressing patients had higher overall symptom scores (p = 0.037), more skin conditions (p = 0.009), and lower total FACT-G and FACT-B scores (p < 0.05). At the time of S-BCRL, detection of greater BIS unit change correlated with higher symptom, skin condition, and QoL values. Greater whole-arm volume change correlated with higher FACT-B+4 scores (all p < 0.05). Conclusions: Prospective surveillance, symptom assessment, and compression intervention promote low progression rates from S-BCRL to C-BCRL and as such reduce symptom burden. This closed study is registered with ClinicalTrials.gov NCT02167659.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Linfedema del Cáncer de Mama / Linfedema Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Lymphat Res Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Linfedema del Cáncer de Mama / Linfedema Tipo de estudio: Diagnostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Lymphat Res Biol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos