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A critical review of "uterine leiomyoma" with subsequent recurrence or metastasis: A multicenter study of 62 cases.
Sanada, Sakiko; Ushijima, Kimio; Yanai, Hiroyuki; Mikami, Yoshiki; Ohishi, Yoshihiro; Kobayashi, Hiroaki; Tashiro, Hironori; Mikami, Mikio; Miyamoto, Shingo; Katabuchi, Hidetaka.
Afiliación
  • Sanada S; Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
  • Ushijima K; Department of Obstetrics and Gynecology, Kurume University, Fukuoka, Japan.
  • Yanai H; Department of Pathology, Okayama University Hospital, Kitaku, Okayama, Japan.
  • Mikami Y; Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan.
  • Ohishi Y; Department of Diagnostic Pathology, Iizuka Hospital, Fukuoka, Japan.
  • Kobayashi H; Department of Obstetrics and Gynecology, Kagoshima University, Kagoshima, Japan.
  • Tashiro H; Faculty of Life Science, Kumamoto University, Kumamoto, Japan.
  • Mikami M; Department of Obstetrics and Gynecology, Tokai University, Isehara, Kanagawa, Japan.
  • Miyamoto S; Department of Obstetrics and Gynecology, Fukuoka University, Fukuoka, Japan.
  • Katabuchi H; Department of Obstetrics and Gynecology, Kumamoto University, Kumamoto, Japan.
J Obstet Gynaecol Res ; 48(12): 3242-3251, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36114691
AIM: Histopathologic diagnosis of a subset of uterine smooth muscle tumors is challenging. We report a critical review regarding the clinicopathological point of view of 62 cases of subsequently recurred or metastasized leiomyoma. METHODS: Medical records and glass slides of 62 cases of uterine smooth muscle tumor diagnosed as leiomyoma, which subsequently recurred or metastasized, were critically reviewed by pathologists specializing in gynecologic pathology and oncology. RESULTS: In 47 (75.8%) of 62 cases, the diagnosis of leiomyoma was confirmed, including 11 intravascular leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML). In 29 cases (46.8%) laparoscopic surgery was performed, of which morcellator without a bag was employed in 23 cases. Fifteen cases (24.2%) appeared to be underestimated and were re-classified as smooth muscle tumor of uncertain malignant potential (STUMP), leiomyosarcoma, or other malignant mesenchymal tumors. Recurrences in seven cases (11.3%) were interpreted to be a malignant transformation, and one STUMP recurred as STUMP. CONCLUSION: The recurrence or metastasis in cases of "leiomyoma" is attributed to iatrogenic or under-evaluation of primary tumors, although a subset of cases is a rare example of biological progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uterinas / Tumor de Músculo Liso / Leiomiomatosis / Leiomiosarcoma / Mesenquimoma Tipo de estudio: Clinical_trials Límite: Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uterinas / Tumor de Músculo Liso / Leiomiomatosis / Leiomiosarcoma / Mesenquimoma Tipo de estudio: Clinical_trials Límite: Female / Humans Idioma: En Revista: J Obstet Gynaecol Res Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia