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Ortho C-H Hydroxyalkylation or Methylation of Aryl Iodides by Ethers and TMSI via a Catellani Strategy.
Zhang, Zhe; Chen, Xi; Li, Xue-Song; Wang, Cui-Tian; Niu, Zhi-Jie; Zhang, Bo-Sheng; Liu, Xue-Yuan; Liang, Yong-Min.
Afiliación
  • Zhang Z; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Chen X; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Li XS; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Wang CT; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Niu ZJ; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Zhang BS; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Liu XY; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
  • Liang YM; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Org Lett ; 24(38): 6897-6902, 2022 09 30.
Article en En | MEDLINE | ID: mdl-36112971
In this paper, in the presence of trimethylsilyl iodide, the direct ortho-C-H hydroxyalkylation/methylation of aryl iodines was effectively realized via palladium/norbornene cooperative catalysis when low-cost tetrahydrofuran and 1,2-dimethoxyethane were used as alkyl sources. Heck, Suzuki, and Sonogashira coupling and hydrogenation were all compatible with the reaction as termination steps. In addition, neuromuscular agents and cardiovascular agents were synthesized in one step by this method, showing their potential application value.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Éteres / Yoduros Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Éteres / Yoduros Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos