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Tripterygium glycoside tablet attenuates renal function impairment in diabetic nephropathy mice by regulating triglyceride metabolism.
Zhang, Jing; Li, Si-Lan; Lin, Wen; Pan, Rong-Hua; Dai, Yue; Xia, Yu-Feng.
Afiliación
  • Zhang J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
  • Li SL; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
  • Lin W; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
  • Pan RH; The Chinese Traditional Medical Hospital of Liyang City, Liyang 213300, China.
  • Dai Y; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China. Electronic address: yuedaicpu@cpu.edu.cn.
  • Xia YF; School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China. Electronic address: yfxiacpu@126.com.
J Pharm Biomed Anal ; 221: 115028, 2022 Nov 30.
Article en En | MEDLINE | ID: mdl-36108463
Tripterygium glycoside tablet (TGT) has been used clinically to alleviate diabetic nephropathy (DN) for decades. However, the mechanism of its anti-DN has not been fully clarified. The aim of this study was to elucidate molecular mechanism of TGT in repairing renal function injury. The results of biochemical parameters and renal histopathology implied that TGT intervention could attenuate creatinine, albumin excretion rate and histological injury of kidney in DN mouse model. Moreover, UHPLC-QTOF-MS/MS-based untargeted metabolomic analysis indicated that 11 metabolites in kidney of mice with DN were restored after TGT treatment, and the most prominent metabolic alteration was triglyceride (TG) metabolism. Mechanistically, TGT effectively improved the function of impaired kidney by promoting TG catabolism via modulation of adipose triglyceride lipase in DN mice. Our findings identified the link between circulating metabolites and DN, suggesting that it might be a possibility to intervene in DN by targeting metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicósidos Cardíacos / Diabetes Mellitus / Nefropatías Diabéticas / Insuficiencia Renal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicósidos Cardíacos / Diabetes Mellitus / Nefropatías Diabéticas / Insuficiencia Renal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Pharm Biomed Anal Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido