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Screening of biomarkers associated with diagnosis and prognosis of colorectal cancer.
Cui, Mingfu; Zhang, Haiyan; Han, Songyun; Huo, Feng; Shen, Zhaoming; Ding, Dayong.
Afiliación
  • Cui M; Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital, Jilin University.
  • Zhang H; Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital, Jilin University.
  • Han S; Department of Emergency, Tonghua Central Hospital, Jilin University.
  • Huo F; Department of Oncological Surgery, Changchun Tumor Hospital.
  • Shen Z; Department of General Surgery, Changchun People's Hospital.
  • Ding D; Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital, Jilin University.
Genes Genet Syst ; 97(3): 101-110, 2022 Oct 18.
Article en En | MEDLINE | ID: mdl-36104170
We aimed to explore biomarkers associated with diagnosis and prognosis of colorectal cancer. Differentially expressed protein (DEP) genes were obtained and validated. Moreover, co-expressed genes were screened and their prognostic value was evaluated. In addition, miRNAs that were negatively correlated with DEP genes were identified and used to construct a competitive endogenous RNA network. Furthermore, a support vector machine model was built using DEP genes, and a receiver operating characteristic curve was implemented to confirm its prediction performance. The results showed that only one DEP gene, CCL26, was obtained. Moreover, 43 genes co-expressed with CCL26 were identified, among which six (AP3M2, DAPK1, ISYNA1, PPM1K, PRR4 and RNF122) were linked with the prognosis of colorectal cancer. Besides, the axis RP11-47122.2/RP11-527N22.1-hsa-miR-3192-5p-CCL26 was identified as an lncRNA-miRNA-target gene network. Support vector machine model analysis showed that the area under the curve of CCL26 reached 0.878 based on GEO data and 0.743 based on our protein data. In conclusion, AP3M2, DAPK1, ISYNA1, PPM1K, PRR4, RNF122, CCL26 and hsa-miR-3192-5p appear to be related to the progression of colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / MicroARNs / ARN Largo no Codificante Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Genes Genet Syst Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / MicroARNs / ARN Largo no Codificante Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Genes Genet Syst Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Japón